Scientists may have found a kitchen spice which processes bioactive ingredients for the treatment of metabolic dysfunction with no side effects, according to studies.
Metabolism is a natural chemical process of organisms, including humans with an aim to sustain- life.
Metabolic dysfunction is a condition caused by any interruption of the aforementioned processes.
In other words, metabolic dysfunction induces the production of excess or reduced amount of substances needed to stay healthy.
There are many risk factors associated with the onset of metabolic dysfunction depending on the types of disruption such as abnormal blood glucose metabolism induced type 2 diabetes.
Diseases associated with metabolic dysfunction can be moderate or severe depending on the organs involved, including liver or respiratory failure, cancer, chronic obstructive pulmonary disease (COPD, includes emphysema and chronic bronchitis), and HIV/AIDS.
Some mild condition of metabolic dysfunction can be managed with only lifestyle change, others may require the long-term intake of certain medication accompanied by a healthy diet and moderate exercise such as diabetes.
One group of mice in the risperidone-treated group were fed a diet with 0.05% Biocurcuma™ (curcumin), one of the vehicle-treated group and two other groups received the standard diet.
Curcumin treatment group inhibited the risperidone effect in reducing spontaneous motricity (motor function) but failed to impede de risperidone-induced increase in food intake.
In other words, curcumin failed to reduced de risperidone-induced weight gain and steatosis.but decreased visceral adiposity stored within the abdominal cavity and decreased the risperidone-induced abnormal enlargement of the liver.
Furthermore, curcumin protected the liver enzymes associated with lipid and glucose metabolism against the overexpression in the induction of metabolic dysfunction by modulating the risperidone-induced glucose intolerance and hypertriglyceridemia.
Dr. Auger F, the lead scientist said, "These findings support that nutritional doses of curcumin contained in Curcuma longa extract are able to partially counteract the risperidone-induced metabolic dysfunction in mice".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
With an aim to find a natural compound for the treatment of metabolic dysfunction, researchers examined the potential capacity of curcumin, contained in Curcuma longa extract (Biocurcuma™),in the attenuation of risperidone-induced metabolic dysfunction in an animal model.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the treatment of metabolic dysfunction, researchers examined the potential capacity of curcumin, contained in Curcuma longa extract (Biocurcuma™),in the attenuation of risperidone-induced metabolic dysfunction in an animal model.
The study involved 4 groups of mice were treated once a week, for 22 weeks with an intraperitoneal injection of risperidone (Risperdal) at a dose of 12.5 mpk.
One group of mice in the risperidone-treated group were fed a diet with 0.05% Biocurcuma™ (curcumin), one of the vehicle-treated group and two other groups received the standard diet.
Curcumin treatment group inhibited the risperidone effect in reducing spontaneous motricity (motor function) but failed to impede de risperidone-induced increase in food intake.
Moreover, curcumin treatment group also showed to reduce levels of markers of hepatotoxicity (ALAT, ASAT) and proinflammatory cytokines expression caused by risperidone (Risperdal).
The findings suggested that Curcuma longa extract inhibited metabolic dysfunction through a number of mechanisms involving adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells.
Taken altogether, turmeric and its bioactive compound curcumin may be considered functional remedies for the treatment of syndrome and diseases associated with metabolic dysfunction, pending to the confirmation of the larger sample size and multicenter human study.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice by Auger F1,2, Martin F3,4,5,6, Pétrault O2,7, Samaillie J3,8, Hennebelle T3,8, Trabelsi MS4,5,6, Bailleul F3,8, Staels B3,4,5,6, Bordet R2, Duriez P. (PubMed)
(2) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals by Aggarwal BB. (PubMed)
Intake of turmeric in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice by Auger F1,2, Martin F3,4,5,6, Pétrault O2,7, Samaillie J3,8, Hennebelle T3,8, Trabelsi MS4,5,6, Bailleul F3,8, Staels B3,4,5,6, Bordet R2, Duriez P. (PubMed)
(2) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals by Aggarwal BB. (PubMed)
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