Thursday, 28 March 2019

Herbal Ginger, The Potential Anti Male Infertility Functional Remedy, Researchers Find

By Kyle J. Norton

Infertility is a reproductive disease characterized by the failure to produce a pregnancy after 12 regular unprotected sexual intercourse, including pregnancy that can not be carried to term.

Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).

Believe it or not, only a very small number of such group are seeking help from the professionals.

In women, certain risk factors including age, excessive, or very low, body fat, medical conditions such as diabetes, hormone imbalance, previous miscarriage and unhealthy lifestyle, such as smoking, excessive alcohol consumption may affect the ovulation of a woman.

In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.

In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.
*Try to be financial stability before having children.
* Too young to be a parent, raising a child needs efforts, time and money.
* Enjoy the couple childless years before committing.

Some researchers suggested that the widespread obesity in North America may be the major factors correlated to the increased infertile rate over the past few decades.

Dr. the lead scientist in the concern of obesity in the risk women infertility, wrote, "Obesity has detrimental influences on all systems, including reproductive health. The prevalence of obesity in infertile women is high, and it is well known that there is an association between obesity and infertility".

And, "Overweight women have a higher incidence of menstrual dysfunction and anovulation. Overweight and obese women are at high risk for reproductive health. The risk of subfecundity and infertility, conception rates, miscarriage rates, and pregnancy complications are increased in these women".

The results suggested that if you are obese, your risk of infertility is higher compared to normal weight women

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine fro the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In the course of the continued efforts to discover a natural remedy for the treatment of infertility, researchers investigated the ginger activity on male reproductive functions.

The randomized double-blind, placebo-controlled trial included 100 infertility treatment candidates admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran.

Patients were randomly assigned to receive one of two treatments: ginger and placebo. Patients were given a 3-month oral treatment (members received capsules containing 250 mg of ginger powder twice a day in ginger and a placebo in another group).

At the end of the experiment, according to the sperm DNA fragmentation (SDF) analysis, the ginger treatment group showed a significant lower of the average positive percentage of SDF compared to the placebo group.

However, there were no significant differences in other semen parameters between the two groups.

The finding clearly suggested that ginger improves the SDF profile in the infertile men.

In order to reveal more information about ginger anti-male infertility activity, researchers investigated the preventive effects of ginger and turmeric rhizomes on some biomarkers of male reproductive function in L-NAME-induced hypertensive rats.

Male Wistar rats selected to the study were divided into seven groups (n = 10): normotensive control rats; induced (L-NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively.

After 14 days of pre-treatment, the animals were induced with hypertension by oral administration of L-NAME (40 mg/kg/day).

Application of L-NAME showed a significant decrease in serum total testosterone and epididymal sperm progressive motility without affecting sperm viability in hypertensive rats.

Hypertensive rats exerted an increase of oxidative stress by decreasing the level of antioxidant enzymes produced by the rats.

Furthermore, hypertensive rats also displayed a decreased testicular and epididymal NO level with concomitant elevation in arginase activity that affects the sperm counts.

Dietary supplementation with turmeric or ginger efficiently normalized the alterations in biomarkers of reproductive function in hypertensive rats.

Dr. Akinyemi AJ, and colleagues wrote, "The inhibition of arginase activity and increase in NO and testosterone levels by both rhizomes could suggest a possible mechanism of action for the prevention of male infertility in hypertension".

Taken altogether, ginger used alone or combined with turmeric may be considered functional remedies for the prevention and treatment of male infertility, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1)The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial by Hosseini J1, Mardi Mamaghani A2, Hosseinifar H2, Sadighi Gilani MA3, Dadkhah F2, Sepidarkish M4. (PubMed)
(2) Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats by Akinyemi AJ1,2,3, Adedara IA4,5, Thome GR3, Morsch VM3, Rovani MT6, Mujica LKS6, Duarte T7, Duarte M7, Oboh G1, Schetinger MRC3. (PubMed)
(3) Impact of obesity on infertility in women by Zeynep Özcan Dağ1 and Berna Dilbaz. (PMC)

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