Hyperlipidemia is a condition of abnormally high blood cholesterol in the bloodstream. The condition is also a member of the cluster of metabolic syndrome associated with the risk type II diabetes and cardiovascular disease.
Cholesterol is a waxy substance with a double-edged sword. On one hand, cholesterol is essential for the body to build strong cellular membranes, production of steroids hormones, and vitamin D and aided digestion, on another hand, it also causes a number of diseases if overexpressed in the blood.
Cholesterol is either produced by the liver or by the intake of fat.
There are 2 types of cholesterol in the body, the low-density lipoprotein (LDL, bad cholesterol) and high-density lipoprotein (good cholesterol).
Where high-density lipoprotein (HDL, good cholesterol) plays a critical role to return the cholesterol to the liver for future use. Low levels of high-density or high levels lipoproteins may result in blood cholesterol accumulated in the blood, leading to high blood cholesterol.
The optimized ratio of LDL/ HDL is any numbers that less than 4.
Dr. Joan Carles Escola`-Gil, the lead scientist in the evaluation of the Western diet risk of high blood cholesterol wrote, ". The HFHC diet caused a significant increase in plasma cholesterol, HDL cholesterol, and liver cholesterol and enhanced macrophage-derived [ 3 H]cholesterol flux to feces by 3- to 4-fold".
In other words, long-term intake of high-fat diet induced hyperlipidemia.
and often in the greenhouse.
With an aim to find a natural ingredient or whole food for the treatment of hyperlipidemia, researchers examined the effect of tomato and grape pomace to the cholesterol (0.3%) diet of male Wistar rats produced a dose-dependent effect.
However, 15% pomace of tomato and grape reduced serum cholesterol levels from 4.4 mmol/L to 2.5 mmol/L and 2.0 mmol/L respectively.
Serum lycopene concentration was also found to have a positive correlation with the expression of Claudin-5 associated with brain microvascular endothelial cell proliferation, migration. and the number of neurons in hippocampal CA1 and CA3.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) The dose-response effect of lycopene on cerebral vessel and neuron impairment induced by hyperlipidemia by Wang W, Yang W, Shen Z, Wen S, Hu M. (PubMed)
(2) Dietary tomato and grape pomace in rats: effect on lipids in serum and liver, and on antioxidant status by Bobek P. (PubMed)
(3) The Cholesterol Content of Western Diets Plays a Major Role in the Paradoxical Increase in High-Density Lipoprotein Cholesterol and Upregulates the Macrophage Reverse Cholesterol Transport Pathway by Joan Carles Escola`-Gil, Gemma Llaverias, Josep Julve, Matti Jauhiainen,Jesu´s Me´ndez-Gonza´lez, Francisco Blanco-Vaca