3,3'-Diindolylmethane or DIM may be used as a bioactive compound for the treatment of colorectal cancer with no side effects, according to studies.
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.
According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.
Dr. Alan Moss, the lead scientist in the evaluation of the association of between diet and colorectal cancer risk, wrote, "Studies that examined dietary factors and various cancers showed that one of the strongest associations is between CRC and meat consumption"
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers in the concern of the slow growth of colorectal cancer and the prognosis in colorectal cancer patients examined the effects of 3,3'-Diindolylmethane (DIM) on cyclin D1, which was aberrantly overexpressed in colorectal cancer cells and tumors.
Where cyclin D1 is a protein needed for cellular proliferation in the G1 phase of the cell cycle.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells by Zhang X1, Sukamporn P2, Zhang S3, Min KW4, Baek SJ. (PubMed)
(2) 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells by Lee SH1, Min KW, Zhang X, Baek SJ. (PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
Alan Moss, and Kumanan Nalankilli. (Gastroenterology)