Scientists may have found a bioactive ingredient for the treatment of pancreatic cancer with no side effects, according to studies.
Pancreatic cancer is a medical condition characterized by irregular cell growth in the tissue of the pancreas.
Most cases of pancreatic cancer start in the cell on the surface of the inner lining of the pancreatic tissue, before penetrating into the deeper layers to form a large and invasive tumor.
At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.
According to the statistic, in the US, every year, approximately 55,440 adults (29,200 men and 26,240 women) are diagnosed with pancreatic cancer.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
On finding a bioactive ingredient for the treatment of pancreatic cancer, researchers investigated the 3,3'-Diindolylmethane (DIM), ring-substituted DIMs and 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl) methanes (C-DIMs) against the growth of Panc-1 and Panc-28 pancreatic cancer cells.
Glucose-regulated protein 78, a protein in the endoplasmic reticulum in the cell played an important role in cellular adaptation and oncogenic survival also increased by the injection of both DIM and DIM-C-pPhtBu.
At similar doses, DIM reduced cell viability and caused cell growth inhibition and apoptosis.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5,Abdelrahim M1, Newman K, Vanderlaag K, Samudio I, Safe S. (PubMed)
(2) Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM) by Azmi AS1, Ahmad A, Banerjee S, Rangnekar VM, Mohammad RM, Sarkar FH. (PubMed)
(3) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)