Tuesday, 26 March 2019

Herbal Ginger Detoxes Liver Acute Toxicity and Improves Liver Functioning In ViVo, According to Studies

By Kyle J. Norton

The functions of the liver are to filter out blood coming from the digestive tract, before passing it to the rest of the body.

In another world, liver inhibits chemical toxin and other harmful by-products such as medication before distributing the clean blood to nourish the body.

In details, the liver also plays a critical role in bile production for the digestive system in breaking down food, and excretion of bilirubin to clear waste products, production of cholesterol for building the cell wall membrane and vitamin D secretion as well as steroid hormones.

According to the statistics, provided by the World Health Organization, liver diseases affect the largest population worldwide, representing 46% of global diseases.

Out of 35 million people in the world die of chronic diseases, 59% are liver diseases and 59% of the mortality is because of chronic diseases.

Jaundice, persistently abdominal pain and swelling, swelling in the legs and ankles, chronic fatigue and gastrointestinal discomforts, particularly persistent itchy skin,  dark urine color, and pale stool are some common signs and symptoms of liver problems.

Although there are many risk factors associated with the onset of liver diseases, excessive alcohol drinking may be the major cause of liver diseases in the Western world, besides hepatitis C infection.

Dr. Radan Bruha, in the evaluation of alcoholic liver diseases, wrote, "Alcohol consumption is directly associated with liver disease mortality and accounts for elevated social and economic costs. Alcoholic liver disease (ALD) may take the form of acute involvement (alcoholic hepatitis) or chronic liver disease (steatosis, steatohepatitis, fibrosis, and cirrhosis)".

And, " The severity and prognosis of alcohol-induced liver disease depend on the amount, pattern and duration of alcohol consumption, as well as on the presence of liver inflammation, diet, nutritional status and genetic predisposition of an individual. While steatosis is an almost completely benign disease, liver cirrhosis is associated with marked morbidity, mortality and life expectancy shortening. The median survival of patients with advanced cirrhosis is 1-2 years. Severe acute alcoholic hepatitis (AH) is associated with mortality as high as 50%".

The results strongly suggested that excessive alcohol drinking overtime will definitely cause alcoholic liver disease.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists on finding a natural remedy in improving liver functionings examined the effects of 6-gingerol on the biochemical parameters and ovarian histological improvements in estradiol valerate (EV) induced PCOS rats.

36 female Wistar rats included in the study were divided into 4 groups: control, received normal diet, PCOS control, received 4 mg/kg EV injection for 28 days and two experimental groups, received an EV injection for 28 days and followed by 6-gingerol (200 μg/kg and 400 μg/kg) for 14 days.

Before application of 6-gingerol, group administrated by EV showed an increase of body and ovarian weights, abnormality in serum sex steroid profile and proinflammatory cytokines and a decrease of antioxidant activity associated to the increase of total cholesterol (TC), low-density cholesterol (LDL-C), triglycerides.

However, pretreatment 6-gingerol treatments, particularly the 400 μg/kg dose, restored the alteration back to the normal and improved liver in the regulation of lipid profile.

The findings suggested that 6-gingerol processed beneficial effects in PCOS rats by inhibiting the oxidative stress and restoring biochemical parameters to normal and decreasing the cysts in the ovaries and increasing liver functioning.

In order to reveal more information of ginger effect on the liver, researchers also reviewed the liver protective activity of polyphenol-rich food products (e.g., chokeberry, black and green tea, blueberry, olive oil, rosemary, and ginger) from this xenobiotic hepatotoxicity and treatment of this heavy metal-induced liver damage.

Injection of polyphenols showed a strong effect in binding ions of Cd against Cd in the induction of hepatotoxicity.

Although most studies are conducted in animal models, some of them are derived from experimental models that reflect human exposure. Therefore it is safe to assume that some polyphenol-rich food products may be promising protective agents against Cd hepatotoxicity in humans, including ginger.

Taken altogether, ginger used alone or combined with other polyphenol-rich foods may be considered functional remedies for improving the liver functioning with no side effects, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) The effects of 6-Gingerol on reproductive improvement, liver functioning and Cyclooxygenase-2 gene expression in estradiol valerate - Induced polycystic ovary syndrome in Wistar rats by Pournaderi PS1, Yaghmaei P2, Khodaei H3, Noormohammadi Z1, Hejazi SH4. (PubMed)
(2) Review of polyphenol-rich products as potential protective and therapeutic factors against cadmium hepatotoxicity by Mężyńska M1, Brzóska MM1. (PubMed)
(3) Alcoholic liver disease by Radan Bruha, Karel Dvorak, and Jaromir Petrtyl. (PMC)

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