Sunday, 24 March 2019

Plantbased Bioactive Compound Sinigrin, the Anti Fungal Infection Bioactive Compound

By Kyle J. Norton

A fungus is a primitive organism, including mushrooms, mold, and mildew.found in the air, in the soil, on plants, and in water.

Fungi reproduce through tiny spores in the air if you inhale the spores, it may spread to cause a fungal infection that often starts in the lungs or on the skin. 

People with a weakened immune system are more likely to infected by fungi, including the fungus Aspergillus which cause lung infection.

Similar to other bacterias, there are millions of different fungal species on Earth, but only about 300 are known to infect people.

Conventionally, fungal infection is treated with antibiotics, including topical antifungal ointments or oral medications, depending on the severity of the disease.

If you are currently taking antibiotics for the treatment of fungal infection, please make sure that you know all possible side effects for preventive measure.

Most common symptoms of skin fungal infection are red and cracking or peeling skin accompanied by itching, depending on the location of affected skin.

In a serious case of fungal lung infection, accumulated fungus fibers, blood clots, and white blood cells may appear in the lungs or sinuses, leading to coughing up blood or fever, chest pain, and difficulty breathing, depending to the size of the accumulation.

In the seeking a natural compound for the treatment of fungal infection, researchers analyzed the antifungal infection of the roots of twelve plant spades from bath mycotrophic (hosts of YAM fungi) and non‐mycotropic (non‐hosts) families against fungus Cladosporium cucumerimun Ellis & Arch.

2 species from the Brassicaceae such as Chenopodiaceae (Spinacea oleracea L., Beta vulgaris L.)  showed a significant effect on fungus compared to Brassica kaber (DC.) Wheeler, Brassica napus L., Brassica campestris L., Thlaspi arvense L., Raphanus raphasnistrum L. which showed a limit activity.

According to the TLC bioassay, Chloroform extracts of B. Kaber roots appeared to have the greatest quantity of extractable antifungal compounds.

Three antifungal compounds in chloroform extracts from B. Kaber roots were shown to be derived from glucosinolates, containing high amount sinigrin.

The finding strongly supports the use of sinigrin for the treatment of fungal infection.

Furthermore, in the differentiation of the fungitoxicity of allyl‐isothiocyanate (AITC) vapor produced from pure sinigrin against Penicillium expansum, the causal agent of blue mold on pears, 5 mg L−1 AITC‐enriched atmosphere showed the best control of blue mold by exposing fruits for 24 h.

At 1 × 103 conidia mL−1to almost 80% at 1 × 106 conidia mL−1, AITC decreased the percentage of infected wounds, compared to >98% of wounds infected in untreated fruits.

Moreover, AITC treatments were effective up to 24 h after inoculation for Conference and 48 h for Kaiser. AITC treatments also controlled a thiabendazole‐resistant strain of P. expansum, reducing the incidence of the blue mold by 90% in both cultivars.

Dr. M. Mari, at the end of the experiment, wrote, "The use of AITC produced from pure sinigrin or from Brassica junceadefatted meal may be an economically viable alternative to synthetic fungicides against P. expansum".

Taken altogether, sinigrin may be considered a supplement for the prevention and treatment of fungal infection, pending to the confirmation of large sample size and multicenter human study.

However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)

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