Depression is a psychological illness which affects a patient mentally, including thinking and feeling and physically such as loss of interest in physical activity.
The exact causes of depression are not identified. However, some risk factors such as genetic predisposition, personality, stress, and brain chemistry are found to associate with the onset in patients with such a condition.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the course to find a natural agent for the treatment of depression with no side effects, researchers evaluated the chemical compound chrysin found abundantly in honey against chronic unpredictable mild stress (CUMS).
The study included a 28-day oral treatment with chrysin (5 or 20mg/kg) in female mice subjected to CUMS, comparing to the effect of fluoxetine.
Na + /K + -ATPase is an enzyme with a function in maintaining resting potential, affects transport, and regulates cellular volume.
Clinical evidence suggested that Na+, K+-ATPase-induced activation of intracellular signaling participates in the mechanisms underlying patients with mood disorder.
Chrysin (20mg/kg) and fluoxetine improved the BDNF and NGF levels in non-stressed mice and in CUMS treatment mice.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin by Filho CB1, Jesse CR2, Donato F1, Giacomeli R1, Del Fabbro L1, da Silva Antunes M1, de Gomes MG1, Goes AT1, Boeira SP1, Prigol M1, Souza LC. (PubMed)
(2) Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice by Filho CB1, Jesse CR2, Donato F1, Del Fabbro L1, de Gomes MG1, Goes ATR1, Souza LC1, Giacomeli R1, Antunes M1, Luchese C3, Roman SS4, Boeira SP. (PubMed)