Hypoxia is a condition of deficiency in the amount of oxygen reaching the tissues, leading to permanent damage to the brain, liver, and other organs.
In the searching a potential compoundagainstt the onset of hypoxia, researchers examined the neuroprotective potential of 3,3'-diindolylmethane (DIM) in cellular and animal models of Parkinson's disease and lipopolysaccharide-induced inflammation.
DIM also inhibited the induction of hypoxia by CoCl2 through the inhibition of oxidative stress detected by fluorescence microplate assay.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Selective Aryl Hydrocarbon Receptor Modulator 3,3'-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia by Rzemieniec J1, Litwa E1, Wnuk A1, Lason W1, Krzeptowski W2, Kajta M. (PubMed)
(2) 3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions by Park H1, Lee DS2, Yim MJ2, Choi YH3, Park S4, Seo SK4, Choi JS5, Jang WH6, Yea SS6, Park WS7, Lee CM8, Jung WK9, Choi IW. (PubMed)