Wednesday, 13 March 2019

Phytochemical Sinigrin, Kills Cancer Cells, Before They Can Spread, According to Studies

By Kyle J. Norton

Sinigrin may be used as a natural and bioactive compound for killing cancer cells before they can spread, according to studies.

Cancer is a group of diseases characterized by cell growth irregularly in the tissue of the body, including glands and organs due to the alternation of cell DNA.

In normal cells, through the process of mitosis, the new cells are born through the division of one cell into two with an aim to replace cells that have been lost, damaged, or worn out. The cell division cycle is closely regulated and they can give rise to only a limited array of cells.

The characteristics of cancer cell growth are completely different compared to normal cells. The cancer cell can divide indefinitely; They are out of control by the immune system. They don't follow the signals of stop division,.... and they do not have a specific function.

How cancer grows? Most cancers stimulate the production of a new blood vessel for nutrition and the function of producing enzymes that break down normal cells and tissues.

All cancers share the general symptoms of unintended weight loss, loss of appetite, fatigue, and tiredness and gastrointestinal discomforts accompanied by the specific symptoms depending on the location of cancer or the organ that was affected.

Out of a number of risk factors, some researchers suggested the creation of obesity in the modern world may be one of the major risk factor associated with the incidence.

Dr. Nathan A. Berger in the evaluation of obesity and risk of cancer wrote, "Overweight and obesity have reached pandemic levels on a worldwide basis and are associated with increased risk and worse prognosis for many but not all malignancies".

And, " lessons learned from the use of murine models to study the association, the impact of obesity on pancreatic cancer, the effect of dietary fats and cholesterol as cancer promoters, and the mechanisms by which the intestinal microbiome affects obesity and cancer".

The results showed a relationship between unhealthy diet risk of obesity in the induction of cancer.

Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers on finding a natural compound for the treatment of cancers examined sinigrin, the bioactive ingredient in cruciferous vegetables for their health benefits and cancer prevention properties in vitro against HL60 (human promyelocytic leukemia cell line) systems.

According to the HL60 assays, sinigrin showed the tumoricidal activity of plant samples (IC50 = 0.28 mg·mL(-1)) by breaking down the products of sinigrin hydrolysis.

Sinigrin also exerted a significant effect in the induction of tumor genotoxicity and proliferation with causing harm to the nearby healthy cells.

The finding strongly suggested that the efficacy of cruciferous vegetables in inducing cancer cell death and proliferation was attributed to the presence of bioactive ingredient sinigrin.

Furthermore, in a model of carcinogen-induced hepatotoxicity in rats, injection of sinigrin significantly inhibited the proliferation of liver tumor cells without inducing liver toxicity.

Injection of the compound for a period of 3 months exhibited pro-apoptotic activity against liver cancer by activating the tumor suppressive gene in the rats.

The active bioactive compound also inhibited the cancer cell proliferation through deactivating the production of proteins associated with liver cancer cells differentiation.

The effect of sinigrin against liver cancer is also found to cancer cell cycle arrest in the in G0/G1 phase.

The results clearly suggest that sinigrin processes important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats.

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of cancer, pending to the confirmation of large sample size and multicenter human study.

However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Antigenotoxicity and Tumor Growing Inhibition by Leafy Brassica carinata and Sinigrin by Lozano-Baena MD1, Tasset I2, Obregón-Cano S3, de Haro-Bailon A4, Muñoz-Serrano A5, Alonso-Moraga Á. (PubMed)
(2) Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats by Jie M1, Cheung WM1, Yu V1, Zhou Y1, Tong PH1, Ho JW. (PubMed)
(3) Obesity and cancer pathogenesis by Nathan A. Berger. (PMC)

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