Inflammation is a natural response induced by the immune system in which the white blood cells in the first line of defense try to destroy the harmful pathogens before they can enter the body to multiply in the acute phase of infection
However, overproduction of pro-inflammatory cytokines in this phase can cause damage to the nearby healthy cells, leading abnormal production of collagen ratio in the initiation of scars forming.
Most pathogens are stopped in the acute phase of infection, depending on the location and the size of the wound and tissues damage.
If the immune system can not kill off all invaded pathogens with a set of period of time, it will compromise, leading to the low-grade chronic inflammation with the persistent production of pro-inflammatory cytokines in the affected area.
Long-term low-grade inflammation ultimately leads to tissues and organs damage, inducing a number of chronic illness, including diabetes and cardiovascular disease.
Symptoms of low-grade chronic inflammation include body pain as in arthritis, constant fatigue and insomnia as in cancer, depression, anxiety and mood disorders due to pain. gastrointestinal complications like constipation, diarrhea, and acid reflux, unintended weight loss or gain depending on the infected tissues and organs.
According to statistics, chronic inflammatory diseases affects approximately 350 million people worldwide and nearly 43 million people in the United States or almost 20% of the population. The prevalence of diseases associated with chronic inflammation is anticipated to increase persistently for the next 30 years, causing a financial burden on the economy and health care sector.
With an aim to find a natural compound for the treatment of diseases associated with chronic inflammation, including cancers, researchers examined the effects of the turmeric through its bioactive components.
According to the review of previous studies, turmeric oil, present in turmeric, can enhance the bioavailability of curcumin.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric by Aggarwal BB1, Yuan W, Li S, Gupta SC. (PubMed)
(2) Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis by Murakami A1, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. (PubMed)