Wednesday, 20 March 2019

Ginger, May Detox Your Liver Against Toxicity, According to Studies

By Kyle J. Norton

Hepatotoxicity is a condition caused by the accumulation of toxin in the liver, leading to liver dysfunction or reduced liver function.

Acute liver toxicity is caused by short-term exposure to toxic chemicals such as overdose of medication.

Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long term use of certain medicines.

The liver is a large internal organ of the human body that protects us by filtering the blood come from the digestive system before passing to other parts of the body.

In other words, if the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.

Epidemiological studies suggested liver dysfunction can also induce acute kidney injury (AKI), chronic kidney disease, linked to the increased mortality, extending to those with chronic liver disease.

There are many causes associated with liver toxicity including chemicals toxins, which normally induces acute liver toxicity, such as those used in laboratories and industries, natural chemicals and long-term use of certain medication.

In the Western world, acute and chronic liver toxicity mostly are caused by long-term excessive alcohol drinking and long-term use of medication in the elderly.

Most common signs and symptoms of liver toxicity may include jaundice, abdominal pain, gastrointestinal discomforts, fatigue, Stomach pain. Nausea (upset stomach) Unusual tiredness. dark-colored urine, and pale-colored bowel movements.

If you are experiencing some of the above signs and symptoms, please check with your doctor to rule the possibility of liver toxicity.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists in finding a natural compound for the treatment of liver dysfunction investigated the ginger effect against Aflatoxin B1 (AFB1) induced liver toxicity.

Male Wistar rats induced liver toxicity by Aflatoxin B1 (AFB1) were orally treated with GE (100 and 250mg/kg) daily, accompanied by the administration of AFB 1 (200μg/kg) every alternative day for 28days.

In vitro and in vivo, pretreatment of HepG2 cells with GE significantly inhibited the production of intracellular reactive oxygen species (ROS), DNA strand break associated with the cytotoxic activity and cytotoxicity induced by AFB1.

In the study of male Wistar rats were orally treated with GE (100 and 250mg/kg) daily, with the administration of AFB 1 (200μg/kg) every alternative day for 28days, application of GE showed a significantly reduced AFB1 induced toxicity observed by the reduced serum markers associated with liver damage.

Furthermore, injection of GE showed the significant hepatoprotective effect by reducing not only the lipid peroxidation but also by enhancing the antioxidant enzymes produced by the host of tested animals.

Moreover, the administration of GE also protected the liver against toxicity through exhibiting the Nrf2/HO-1 pathway associated with the inhibition of inflammation and oxidative stress.

Additionally, in order to reveal more information about ginger hepatoprotective activity, researchers examined ginger activity in preventing antituberculosis drug-induced hepatotoxicity in patients with tuberculosis.

Patients selected to the study were divided into the ginger and placebo groups (30 patients in each group). Patient in each group was given either 500 mg ginger (Zintoma)(®) or placebo one-half hour before each daily dose of antituberculosis drugs for 4 weeks.

During the study period, 26.7% of patients experienced antituberculosis drug-induced hepatotoxicity. 

Treatment of ginger group experienced less liver toxicity in percentage, compared to the placebo group.

The results of the study strongly supported the use of ginger as a potential treatment of liver toxicity caused by adverse effects of some conventional medicine.

Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of liver toxicity, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Protective effects of phenolics rich extract of ginger against Aflatoxin B1-induced oxidative stress and hepatotoxicity by A V V1, K RR1, Kurrey NK2, K A AA1, G V3. (PubMed)
(2) Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial by Emrani Z1, Shojaei E2, Khalili H. (PubMed)

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