Wednesday, 20 March 2019

Honey May Be Better Than Prednisolone for Acute and Chronic Pain Relief, According to Scientists

By Kyle J. Norton

Antinociception is the process which blocks sensory neurons respond to potentially damaging stimuli associated with pain.

Pain is a natural reaction with an aim to protect our body against danger or damage.

Acute pain is the pain that lasts less few weeks.

Chronic pain is pain that lasts more 6 months.

Chronic pain has been found to be the most common reason for someone to see his/her physician.
 Chronic pain in some cases was a major symptom of a medical condition that can only be treated physically and mentally through pain management.

However, most cases of chronic pain are associated with injury, such as a back sprain, or there may be an ongoing cause, such as illness.

Chronic pain can interfere with a person's quality of life and general functioning. 

According to statistics provided by Dr. Donald Schopflocher, lead scientists in the evaluation of the prevalence of chronic pain in Canada, researchers wrote, "The prevalence of chronic pain for adults older than 18 years of age was 18.9%".

And, "Chronic pain prevalence was greater in older adults, and females had a higher prevalence at older ages compared with males. Approximately one-half of those with chronic pain reported suffering for more than 10 years. Approximately one-third of those reporting chronic pain rated the intensity in the very severe range".

Chronic pain according to the study is very common, affecting approximately 19% of Canadian over 18 years of age, mostly in older adults.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a potential natural whole food for pain relief examined the Tualang honey (Fēng Mì) and prednisolone on the nociceptive response in male Sprague-Dawley rats.

35 male Sprague-Dawley rats selected to the study were divided into 5 groups. Each group was given either distilled water, Tualang honey (0.2, 1.2 or 2.4 g/kg) or prednisolone (10 mg/kg) for 10 days.

Where prednisolone is a steroid medication used for pain relief.

According to the response to a noxious thermal stimulus using tail flick test on Day 10, the tail flick latency time was significantly higher in the groups that received 1.2 g/kg and 2.4 g/kg of Tualang honey and 10 mg/kg of prednisolone, compared to the control group.

Compared to the groups treated with prednisolone or distilled water, Tualuang honey treatments showed no effects on other parameters.

In other words, Tualang honey treatment group showed signs of abnormal behavior, such as total food pellet intake or weight loss.

Dr. Aziz CB, the lead scientist at the Universiti Sains Malaysia, said, "preemptive administration of Tualang honey (1.2 g/kg and 2.4 g/kg) and prednisolone (10 mg/kg) had reduced the pain responses".

Based on these results, Tualang honey processes a strong antinociceptive better than those of corticosteroids (prednisolone).

In order to reveal more information about honey antinociceptive activity, researchers compared several kinds of honey pain relief efficacy.

Acacia honey showed most effective dose-dependent antinociceptive activity compared to the untreated group in tail-flick and paw-withdrawal tests, respectively.

Most tested honey exerted antinociceptive activity of reaching the maximum at 60 min post-treatment then gradually decreased, whereas the activity of indomethacin was persistent at 120 min post-treatment.

Interestingly, the major constituents found in honey such as fructose, glucose, maltose, and sucrose used alone do not demonstrate any effect compared to the whole food.

The results strongly suggested that there must be other compounds in the honey that process a significant antinociceptive property or all active ingredients in honey work together to stimulate the pain relief activity.

Taken altogether, honey, particularly, Tualang and Acacia honey may be considered a functional remedy for acute and chronic pain relief, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) The antinociceptive effects of tualang honey in male sprague-dawley rats: a preliminary study by Aziz CB1, Ismail CA1, Hussin CM2, Mohamed M. (PubMed)
(2) Antinociceptive activity of natural honey in thermal-nociception models in mice by Azim MK1, Perveen H, Mesaik MA, Simjee SU. (PubMed)
(3) The prevalence of chronic pain in Canada by Donald Schopflocher, PhD,1,2 Paul Taenzer, PhD,3 and Roman Jovey, MD. (PubMed)

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