Colorectal cancer is a medical and chronic condition caused by irregular cell growth in the colon or rectum.
Colorectal cancer is one of the slowest growth of cancer. Therefore, Most cases of colorectal cancer are discovered in the later stage, causing a high rate of mortality.
According to the study, at the advanced stage, the median survival of patients is 24 months (range 16–42). The one-year and 2-year survival rate is 65% and 25%, respectively.
Most cases of colorectal cancer start in the cells on the surface of the inner lining of the colon or rectum. At the early stage, due to the small size of the tumor, most patients are asymptomatic.
However, at the advanced stage, the oversize tumor may suppress the nearby blood vessels and nerve cells, leading to persistently severe bleeding and pain.
Patients at this stage may also experience symptoms of a change in bowel habits, including diarrhea or constipation or consistency of the stool, that lasts longer than four weeks.
If you experience some of the aforementioned symptoms, please make sure that you check with your doctor immediately to rule out the possibility.
The exact causes of colorectal cancer are not identified. Out of many risk factors associated with the onset of the disease, aging may be one of the major cause, as most cases of colorectal cancer are diagnosed in adults over the age of 50, and the risk increases with age.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a potential and natural compound for the treatment of colorectal cancer examined diindolylmethane (DIM) effect on cyclin D1, which was aberrantly overexpressed in various cancer cells and tumors.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells by Zhang X1, Sukamporn P2, Zhang S3, Min KW4, Baek SJ. (PubMed)
(2) FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethaneinhibits migration and invasion of human colorectal cancer cells by Jin H1, Li XJ1, Park MH2, Kim SM. (PubMed)
(3) Survival of untreated advanced colorectal cancer patients by G.P. STATHOPOULOS, (PMC)