Tuesday, 26 March 2019

Herbal Artichoke, the Potential Anti Lymphoma Natural Remedy, According to Researchers

By Kyle J. Norton 

Lymphoma originated in the lymphatic system is a type of cancer that affects the white blood cells lymphocytes of the immune system.

Non-Hodgkin's lymphomas are the most common types of lymphoma 

According to statistics provided by the Leukemia and Lymphoma Society, in the US, approximately over 1,30,000 people are either living with or are in remission from, leukemia, lymphoma or myeloma, causing the death of over 9% of all cancer death in 2018.

 60 years of age and over, weakened immune system, previous exposure to toxic chemicals, previous chemotherapy or radiation therapy are some of the most common prevalent risk factors of lymphoma.

Interestingly, most people with some of the above risk factor have never developed lymphoma.

Some researchers suggested that people infected by the HIV virus are also at an increased incidence of the disease, probably due to immune suppression.

Dr, K L Grogg, in the concern of immune deficiency in patients infected by the HIV virus in the risk of lymphoma said, The incidence of lymphoma in patients with HIV infection greatly exceeds that of the general population.

And, "The increased risk for lymphoma appears related to multiple factors, including the transforming properties of the retrovirus itself, the immunosuppression and cytokine dysregulation that results from the disease, and, most importantly, opportunistic infections with other lymphotropic herpes viruses such as Epstein–Barr virus and human herpesvirus 8".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural chemo compound for the treatment of lymphoma examined the anticancer activity of the sesquiterpene lactone, the major constituent of the artichoke leaves extracts.

The aim of the study was to investigate the effects of cynaropicrin, a major compound from the sesquiterpenes on the grown of a number of leukocyte cancer cell lines.

Injection of cynaropicrin exerted potently effect in inhibiting the proliferation of leukocyte cancer cell lines, such as U937.

According to the flow-cytometric assay, cynaropicrin displayed a strong inhibition against the cancer cell line by exhibiting the expression of free radical cytotoxic effect.

The cancer cell apoptosis in the cell cycle arrest at G1/S phase observed by the DNA fragmentation and morphological analyses in U937.

Use the combination of antioxidants such as l-cysteine and N-acetyl-l-cysteine, reactive oxygen species scavengers showed to reduce the cytotoxic activity of the cynaropicrin against U937.

These results clearly suggested that mediation of reactive oxygen species and protein associated with the pro-apoptotic activity were attributed to the effect of cynaropicrin in the inhibition of lymphoma cancer.

Dr. and colleagues after taking into account co and confounders wrote in the final report, "cynaropicrin may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro-apoptotic activity".

Taken altogether, artichoke processed abundantly bioactive compound sesquiterpene lactone cynaropicrin may be considered a functional remedy for the prevention and treatment of lymphoma, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines by Cho JY1, Kim AR, Jung JH, Chun T, Rhee MH, Yoo ES. (PubMed)
(2) HIV infection and lymphoma by K L Grogg, R F Miller, and A Dogan. (PMC)

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