3,3'-Diindolylmethane may be the next bioactive compound for the treatment of melanoma with no side effects, according to studies.
Melanoma is skin cancer caused by the alternation of melanocytes DNA in the skin pigment, leading to the formation of moles that change in the color, size or shape on the skin.
Researchers on finding a natural compound for the treatment of melanoma compared the effects of
kaempferol (Kem), genistein (Gen), and 3'3-diindolylmethane (DIM) on melanoma cell viability.
DIM exerted the strong inhibition against the A375SM melanoma cells by increasing the tumor suppressive gene expression, p21 and decreasing the gene expression associated with the cancer cell proliferation and survival.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Phytochemical-induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and differentiation in malignant melanoma cells by Heo JR1, Lee GA1, Kim GS1, Hwang KA1, Choi KC. (PubMed)
(2) Novel 3,3'-diindolylmethane derivatives: synthesis and cytotoxicity, structural characterization in solid state by Maciejewska D1, Rasztawicka M, Wolska I, Anuszewska E, Gruber B. (PubMed)
(3) Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate by Julia A Newton-Bishop, Yu-Mei Chang, Faye Elliott, May Chan, Susan Leake, Birute Karpavicius, Sue Haynes, Elaine Fitzgibbon, Kairen Kukalizch, Juliette Randerson-Moor, David E Elder,* D Timothy Bishop, and Jennifer H Barrett. (PMC)