Wednesday, 17 April 2019

Whole Food Ginger Suppresses Rheumatoid Arthritis

By Kyle J. Norton

Scientists may have found a kitchen pungent spice for the treatment of rheumatoid arthritis with no side effects, according to studies.

Rheumatoid Arthritis is a chronic disorder characterized by inflammation of the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.

According to the statistics provided by the CDC, musculoskeletal disorders (MSDs) affects over 52 millions of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid arthritis was found to induce bone loss through elevating bone resorption without increasing bone formation. 

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.

Patient with rheumatoid arthritis (RA) often associates to valgus deformities of the feet and deformities of gait due to body function due to an effort to support the collapsing longitudinal arch of the foot.  The kinematic and kinetic gait changes in rheumatoid arthritis (RA) are the result of a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,...

Long-term bone damage and the prolonged onset of the disease can induce deformities of hand and wrist and small peripheral joints (such as fingers and wrist) due to chronic inflammation.

The effects of muscle strength in patients with RA may contribute to the prevalence of functional limitations physically that can affect daily living and quality of life.

Furthermore, rheumatoid nodules, lump on the skin, closed to the joint have been found to affect the joints of patients with RA.

Moreover, morning stiffness, a marker of inflammatory activity that reflects functional disability and pain is a very common symptom of patients in early stage of rheumatoid arthritis.

Dr. Motl RW and Dr. McAuley E. in the assessment of chronic diseases said, " The rationale and the associated onset of chronic disease conditions that influence function, disability, and quality of life (QOL) are embedded in the "Graying of America""(29), including patients with RA.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists in seeking a potent natural ingredient or compound for the treatment of rheumatoid arthritis investigated ginger's traditional use as an anti-inflammatory against RA in Chinese and Ayurvedic medicine.

In joint swelling in an animal model of rheumatoid arthritis and streptococcal cell, wall-induced researchers compared crude ginger extract and a fraction containing only gingerols and their derivatives.

According to the assays, both extracts were efficacious in preventing joint inflammation.

However, the crude dichloromethane extract, containing essential oils and more polar compounds, was more efficacious in preventing both joint inflammation and destruction, compared to the fraction.

The results strongly suggested the use of ginger extract for the prevention of joint inflammation and destruction in RA.

Dr. Funk JL and colleagues at the University of Arizona wrote, " these data document a very significant joint-protective effect of these ginger samples and suggest that nongingerol components are bioactive and can enhance the antiarthritic effects of the more widely studied gingerols.

In order to reveal more information about ginger anti-RA property, researchers evaluated the anti-inflammatory effects of ginger's other secondary metabolites, the essential oils (GEO), containing terpenes in female Lewis rats with SCW-induced arthritis.

Injection of GEO (28 mg/kg/d ip) prevented chronic joint inflammation, without altering the initial acute phase of joint swelling and granuloma formation at sites of SCW deposition in the liver.

Compared to pharmacologic doses of 17-β estradiol (200 or 600 μg/kg/d sc), GEO elicited the same pattern of anti-inflammatory activity by its phytoestrogenic activity.

Based on the findings, Dr.Funk JL, the lead scientist wrote again in the final report, "ginger's anti-inflammatory properties are not limited to the frequently studied phenolics, but may be attributable to the combined effects of both secondary metabolites, the pungent-tasting gingerols and as well as its aromatic essential oils".

Take all together, ginger processed a high amount of bioactive compounds and secondary metabolites may be considered a functional alternative for prevention and treatment of RA, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

(1) Anti-Inflammatory Effects of the Essential Oils of Ginger (Zingiber officinaleRoscoe) in Experimental Rheumatoid Arthritis by Funk JL1, Frye JB1, Oyarzo JN1, Chen J1, Zhang H2, Timmermann BN. (PubMed)
(2) Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis by Funk JL1, Frye JB, Oyarzo JN, Timmermann BN. (PubMed)
(3) Most Common Disease of the elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Rheumatoid Arthritis: The Signs and Symptoms by Kyle J. Norton

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