Tuesday, 23 April 2019

Manuka Honey improves the Cellular Antioxidant Defense Enzymes

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a herbal remedy for the treatment of diseases associated with oxidative stress, according to studies.

Free radical or reactive oxygen species are unstable atoms with unpaired electrons on the outermost ring that are ready to donate or intercept an electron from other atoms, leading to a chain reaction which can not be stopped until they all electrons on the outermost ring are paired or inhibited by antioxidants.

On the other hand, antioxidants are stable atoms which inhibit oxidation caused by free radicals.

In healthy individuals, antioxidant enzymes produced by the liver are good enough to balance the free radical produced by the cell metabolism and external sources such as the air we breathe and the food we eat.

However, in people with a weakened immune system such as infants, children and the elderly, dietary sources from supplements, fruits and vegetables may be needed.

Oxidative stress is a result of an imbalance of the ration of free radical and antioxidant in the body. A prolonged period of oxidative stress has been found to cause proteins and lipid damage and alteration of cell DNA inducing chronic diseases such as CVD, diabetes, and cancer.

Believe it or not, free radicals also play a critical role in maintaining a certain body function. The Journal of Physiology showed that free radicals act as signal substances that cause the heart to beat with the correct force.

In other words, Dr. says Håkan Westerblad said, ""Free radicals play an important role since they contribute to the heart being able to pump more blood in stress-filled situations."

And "On the other hand, persistent stress can lead to heart failure, and chronically increased levels of free radicals may be part of the problem here."

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient which enhances the cellular antioxidant defense system against diseases, researchers examined Manuka honey effects in the genotoxic and genoprotective properties in cells activity against free radicals in the ranging from 25-1000 μg/mL.

In a modest decrease of H2O2-induced cellular DNA damage, Manuka honey displayed a stronger potential to attenuate damaged cells at all tested concentrations, particularly in the concentrations of 25 and 100 μg/mL.

More precisely, Manuka honey protected DNA of whole blood cells from oxidative damage induced by hydrogen peroxide in vitro.

Furthermore, Manuka honey exerted a similar activity against free radical overexpression, compared to buckwheat honey which has higher contents of sugars, proteins, and total phenols but a lower content of MGO.

Additionally, Manuka honey also exhibited a strong cellular antioxidant and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa,, compared to those of buckwheat honey.

Where buckwheat honey is considered to have great nutritional and commercial potentials

Taken altogether, Manuka honey may be considered anti hypertension functional remedy for the enhancement of the cellular antioxidant defense system with no side effects, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Biochemical properties, antibacterial and cellular antioxidant activities of buckwheat honey in comparison to manuka honey by Deng J1, Liu R2, Lu Q3, Hao P1, Xu A1, Zhang J2, Tan J. (PubMed)
(2) Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro by Živković L1, Bajić V2, Dekanski D3, Čabarkapa-Pirković A4, Giampieri F5, Gasparrini M5, Mazzoni L6, Potparević BS. (PubMed)
(3)  Mitochondrial production of reactive oxygen species contributes to the beta-adrenergic stimulation of mouse cardiomycytes. by Daniel C Andersson, Jérémy Fauconnier, Takashi Yamada, Alain Lacampagne, Shi-Jin Zhang, Abram Katz & Håkan Westerblad (The Journal of Physiology)

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