Wednesday, 24 April 2019

Cucumber Seed, the Potent Anti Hyperlipidemic Remedy Found In Vivo and Human Study

By Kyle J. Norton

Hyperlipidemia is a medical condition associated with the abnormally high levels of lipid, including cholesterol and fat in the bloodstream.

People with hyperlipidemia are symptomatic. However, depending on the amount of lipid accumulated on the arterial wall, some people in the advanced stage may be at substantial risk to heart disease and stroke.

Hyperlipidemia is a condition of the cluster of metabolic syndrome. If untreated, it can lead to atherosclerosis, a condition of hardening and narrowing of the arteries that facilitates the onset of coronary artery disease.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

Conventionally, hyperlipidemia is treatable. Most patients with the condition are treated by prescribed high-cholesterol medicine statins, such as simvastatin, lovastatin, atorvastatin, and rosuvastatin. 

However, for people with a high risk of cardiovascular diseases, PCSK9 inhibitors, such as Redpath (evolocumab) may be prescribed.

If you are taking medicine to lower your blood cholesterol, please make sure that you know all the side effects for preventive measure.

Although there are many factors that cause the onset of hyperlipidemia, some researchers suggested the promotion of high-fat diet over the past few decades may have strong implication in inducing the rise of hyperlipidemia in the US.

Dr. Cole TG,, the lead scientist wrote, " In normals, dietary cholesterol increases LDL production and decreases LDL receptor-related LDL clearance, resulting in elevations in LDL cholesterol levels of approximately 30 mg/dL".

And, " the effects of high fat and high cholesterol diets on the lipoproteins of individuals with diminished LDL receptors, three kinds of diets, including ones high in cholesterol, were fed to four patients with familial hypercholesterolemia, in the expectation that diet effects on apoB- or apoE-containing lipoproteins would be exaggerated".

The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

In a concern of hyperlipidemia associated with increased risk of atherosclerosis, researchers examined the Cucumber (Cucumis sativus) seed effect on how to control this risk factor for the prevention of atherosclerosis.

The randomized double-blind placebo-controlled clinical trial included hyperlipidemic patients randomly assigned to either Cucumis (n=23) used one medicinal capsule or placebo groups (n=24)used one placebo capsule once daily with food for 6 wks.

According to the tested assays, at the end of the experiment, Cucumis seed extract showed a significant reduction of total cholesterol, triglycerides (TG), low-density lipoprotein (LDL-C), and body mass index (BMI) and a significant increase of high-density lipoprotein (HDL-C), compared to the placebo group.

More precisely, the consumption of C. sativus seed extract with a daily dose of 500 mg exerted a maximum effect on serum lipid profile in adult hyperlipidemic patients.

In other words, cucumber (Cucumis sativus) seed not only reduce the expression of hyperlipidemia but also inhibited the risk of atherosclerosis.

Furthermore, in vivo, researchers in the CVD team at the Sharadchandra Pawar College of Pharmacy evaluated the anti-hyperlipidemic activity of Cucumis melo fruit peel (CMFP) methanolic and aqueous extract in high cholesterol diet-induced hyperlipidemic rats.

Injection of CMFP methanolic and aqueous extract resulted in a significant (P<0.01) reduction in gaining body weight, serum lipid profile like total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) level.  

Compared to the hyperlipidemic control group, the treatment group showed a strong effect on the atherogenic index and increase of the serum high-density lipoprotein cholesterol (HDL-C) levels in 28 days.

Treatment groups also exerted anti-hyperlipidemic activity observed by the increased fecal excretion of bile acids and sterols similar to that of standard drug.

Once again, the administration of a methanolic extract of CMFP at a dose of 500 mg/kg showed higher antihyperlipidemic activity, compared to other extract doses.

Taken altogether, cucumber may be used for the treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Evaluation of the Effects of Cucumis sativus Seed Extracts on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial by Soltani R1, Hashemi M2, Farazmand A1, Asghari G3, Heshmat-Ghahdarijani K2, Kharazmkia A4, Ghanadian SM. (PubMed)
(2) The anti-hyperlipidemic activity of Cucumis melo fruit peel extracts in high cholesterol diet induced hyperlipidemia in rats by Bidkar JS1, Ghanwat DD, Bhujbal MD, Dama GY. (PubMed)
(3) Effects of high cholesterol high fat diet on plasma lipoproteins in familial hypercholesterolemia by Cole TG, Pfleger B, Hitchins O, Schonfeld G. (PubMed)

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