Pain and swelling is a natural response of the immune and nervous system after a wound or injury by inducing the production of proinflammatory cytokines.
In the acute of infection, after sensing a wound and injury of the body, the immune first lines of white blood cell defense stimulate the production of blood palette to the infected area with an aim to cover the wound or injury and the inflammatory cytokines to kill off organisms trying to enter the body through the opening.
Please note that overexpression of proinflammatory cytokines in this phase has been found to cause abnormal healing with the formation of scars.
The acute phase of infection arrives and leaves quickly as it is resolved quickly by the body.
However, chronic infection is a result of an immune system that can not kill off all infectious organisms in the acute phase of infection, leading to chronic inflammation that last a long time, such as months or years.
Swelling and pain on the joints are one of the most common symptoms in patients with arthritis, particularly in rheumatoid arthritis (RA).
However, some cases of swelling accompanied by symptoms that do not associate to the injury such as fatigue, loss of appetite, and weight gain may be an indication of cancer, heart, liver, or kidney disease.
With an aim to find potential and natural compound for the treatment of pain and swelling with no side effects, researchers evaluated the effect of bromelain after surgical removal of third molars.
The randomized, double-blind, placebo-controlled study included 45 patients requiring extraction under local anesthesia of a single partial bony impacted mandibular third molar randomly divided into 1 of 3 groups: bromelain, diclofenac, and placebo.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars by Singh T1, More V2, Fatima U3, Karpe T4, Aleem MA5, Prameela J. (PubMed)
(2) Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial by Majid OW1, Al-Mashhadani BA. (PubMed)