Hypercholesterolemia is a chronic condition associated with abnormally high blood cholesterol in the blood
In other words, hypercholesterolemia is a result of overexpression of low-density lipoprotein compared low levels of high-density lipoprotein.
Low-density cholesterol also is known as bad cholesterol produced by the liver or dietary saturated and trans fat in moderate amount plays a critical role in building a strong cell wall, production of steroid hormones and vitamin D and aiding the gastrointestinal tract in the absorption of nutrients.
However, high levels of bad cholesterol have been found to induce hypercholesterolemia, a leading cause of heart disease and stroke.
High-density lipoprotein or good cholesterol, on the other hand, returns the amount of excess cholesterol back to the liver for future use.
High-density lipoprotein is also produced by the liver and dietary sources found mostly in nut and fish.
The healthy ratio of LDL/HDL is any numbers less than 4.
Although there are many risk factors that cause the onset of hypercholesterolemia, some researchers suggested the introduction of a high-fat diet in North American over the past few decades may accelerate the rise of the condition.
Dr. Cole TG, the lead scientist, in a randomized controlled parallel-designed intervention study to evaluate the effects of a diet with less than 20 g carbohydrates per day (LCHF) on plasma low density lipoprotein cholesterol (LDL-C) in young and healthy adults wrote, "There was a significant increase in apolipoprotein B, total cholesterol, high-density lipoprotein cholesterol, free fatty acids, uric acid and urea in the LCHF group versus controls".
On finding a natural compound for the treatment of hypercholesterolemia, researchers investigated
the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, triglyceride in rats fed with a high cholesterol diet.
In order to reveal more information about alliin anti-high blood cholesterol activity, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia by Peleg A1, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. (PubMed)
(3) Effect of low carbohydrate high fat diet on LDL cholesterol and gene expression in normal-weight, young adults: A randomized controlled study by Retterstøl K1, Svendsen M2, Narverud I3, Holven KB. (PubMed)