Sunday, 28 April 2019

Whole Food Ginger, the Stroke Prevention Functional Remedy

By Kyle J. Norton

Stroke is a medical condition characterized by the death of brain cells as a result of inadequate of oxygen-rich blood flow.

In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagia, due to bleeding.

A stroke is a medical emergency. Early intervention in most cases can minimize brain damage and potential complications.

According to the statistics, in the US, stroke is the leading cause of serious, long-term disability.
Each year, approximately 795,000 people suffer a stroke and recurrent stroke. Most cases of stroke are associated with adults over the age of 65.

Not all strokes can lead to permanent brain damage. Some people with a temporary disruption of blood flow to the brain do not result in permanent damage.

Besides aging, smoking, medical conditions such as unmanaged high blood pressure and cholesterol and diabetes, obesity, physical inactivity are some of the prevalent factors found in stroke patients.

Some researchers suggested a poor diet pattern such as the Western diet may have a strong impact in elevated the risk of stroke in the Western world.

Dr. Sherzai A, the lead scientist wrote, " Stroke is the fourth leading cause of mortality in the United States, yet it is 80% preventable by addressing lifestyle factors including nutrition".

And, "Adherence to DASH, Mediterranean, and prudent dietary patterns reduced the risk of stroke, whereas the Western dietary pattern was associated with increased stroke risk".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural whole food for reducing the risk of stroke researchers examined the effects of ginger in the risk of stroke.

Three candidates from the ginger family identified based on the prediction models in the study were compared to those of the control inhibitor L-454560.

PDE4D inhibitor is a potential drug target used in stroke prevention.

Administration of 3 compounds identified from the ginger family was capable in inhibiting cAMP binding associated with the increase of stroke risk, similar to those of PDE4D.

Genetic polymorphisms of PDE4D (T83C, C87T, and C45T) gene is associated with increased risk of ischemic stroke (IS).

Genetic polymorphisms of ALOX5AP are also associated with ischemic stroke and atherothrombotic events in stroke patients.

In order to reveal more information about ginger anti-stroke risk activity, researchers examined the ginger on the activities of phosphodiesterase 4D (PDE4D) and 5-Lipoxygenase activating protein (ALOX5AP), the two of the major factors involved in the ischemic stroke, accounting for around 80-85% of total stroke.

Injection of ginger not only modulated the expression of PDE4D activities against the activation of cAMP-induced stroke and cardiovascular diseases but also inhibited the overexpression of ALOX5AP that could induce the development of atherosclerosis and stroke through inflammatory pathways.

Take all together, ginger may be considered a functional alternative for the prevention of stroke, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.


(1) In silico pharmacology suggests ginger extracts may reduce stroke risks by Chang TT1, Chen KC, Chang KW, Chen HY, Tsai FJ, Sun MF, Chen CY. (PubMed)
(2) Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once? by Chen KC1, Chang KW, Chen HY, Chen CY. (PubMed)
(3) Stroke, food groups, and dietary patterns: a systematic review by Sherzai A1, Heim LT, Boothby C, Sherzai AD. (PubMed)

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