Thursday, 18 April 2019

Herbal Ginger, The Natural Treatment for Dementia with No Side Effects

By Kyle J. Norton

Dementia is the medical condition characterized by the loss of mental ability, that is severe enough to interfere with people's every life. Alzheimer's disease is the most common type of dementia in aging people.

According to the statistics, about 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years and above that age. 

The causes of dementia are associated with the gradual loss of neurons. Researchers do not know the exact causes of the death of neurons. Neither, they know why people with the same health condition in the same family, some are prone to the disease onset while others do not.

However, they do know certain risk factors are associated with the development of dementia, including
* The increase in age is the strongest known risk factor for dementia.
* Gender 
Women are more likely to develop Alzheimer’s disease than men. 
* Ethnicity
Western people are more likely to develop dementia than people who live in Southeast Asia.
* Long-term use of medication
* Certain medical conditions such as diabetes, high blood glucose and cholesterol, and obesity.

Out of the many risk factors involved the incidence of dementia, aging probably is one of the major cause of the disease.

Dr. P Scheltens and colleagues in the evaluation of the risk factors of dementia wrote, "Prevalence estimates vary highly between studies. These variations may be due to variations in the study population—that is, reflect real differences. For example, age is the most important risk factor for dementia".

And, "In 2000, prevalence data from 11 European population-based studies were pooled to obtain stable estimates of the prevalence of dementia in the elderly (> 65 years)".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of dementia with no side effects examined the traditional medicine use of ginger on dementia.

Epidemiologically, ginger has been known to have disease-modifying effects in Alzheimer's disease (AD).

6-Shogaol, a bioactive compound found in ginger has also recently been shown to process anti-neuroinflammatory effects in lipopolysaccharide (LPS)-treated astrocytes and animal models of Parkinson's disease. 

In a mice model, administration of 6-shogaol significantly reduced microgliosis and astrogliosis in intrahippocampal AβO-injected mice.

6-shogaol injection also ameliorated AβO and scopolamine-induced memory impairment by suppressing the production of proinflammatory cytokine and pre- and post-synaptic markers in the hippocampus.

Researchers after taking into account co and confounders wrote, "All these results suggest that 6-shogaol may play a role in inhibiting glial cell activation and reducing memory impairment in animal models of dementia".

Additionally, in order to reveal more information about Ginger rhizome (Zingiber officinale) used for centuries to treat dementia in South Asia, researchers examined the 70% aqueous/methanolic extract of dried ginger (Zo.Cr) on a dementia model.

On isolated rat stomach fundus, Zo.Cr showed a spasmogenic effect (0.03-5.00 mg mL(-1)) and relaxed the tissue at concentrations > or =5 mg mL(-1).

In atropinized (0.1 microM) preparations, Zo.Cr (0.3-3.0 mg mL(-1)) relaxed high K(+) (80 mM)-induced contractions, indicating the disruption of the Ca(++) channel associated with pain.

6-gingerol was the most potent in inhibition of BuChE. BuChE activity progressively in patients with Alzheimer's disease (AD).

Take all together, ginger processed a high amount of bioactive compounds may be considered a functional alternative for the prevention and treatment of dementia, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

(1) 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia by Moon M1, Kim HG2, Choi JG3, Oh H4, Lee PK5, Ha SK6, Kim SY7, Park Y7, Huh Y8, Oh MS. (PubMed)
(2) Muscarinic, Ca(++) antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia by Ghayur MN1, Gilani AH, Ahmed T, Khalid A, Nawaz SA, Agbedahunsi JM, Choudhary MI, Houghton PJ. (PubMed)
(3) Risk factors of Dementia by Alzheimer's Society
(4) Epidemiology and risk factors of dementia by W M van der Flier, and P Scheltens. (BMJ Journal)

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