Oxidative stress is a condition caused by the imbalance of the ratio of free radicals and antioxidant produced by the host, leading to lipid and protein damage and alternation of cell DNA.
Oxidative stress has been found to initiate the onset of chronic disease, including heart disease, diabetes, and cancers.
Free radicals are unstable atoms with an unpaired electron in the outer ring. Therefore, in order for them to become stable, free radicals are ready to steal or donate an electron from or to other atoms, leading to a chain reaction that can not be stopped until all electrons in the outer ring are paired or inhibited by antioxidants.
Overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.
Antioxidants are stable atoms that inhibit oxidation.
In a healthy individual, antioxidant enzymes by the body are more than enough to accounter the expression of free radicals which bombard our body every day.
However, in less healthy people, intake of dietary antioxidants such as supplement or fruits rich with antioxidants may be the only option to improve levels of antioxidant in the body.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
On finding a natural compound for the treatment of diseases associated with oxidative stress, researchers investigated artichoke antioxidant activity, compared to those of Ficus carica, and Morus nigra and their herbal mixture (CFM) in vitro, using CCl4 induced damage in HepG2 cells.
CFM at 1 mg/ml showed a 47.00% and 37.09% decline of aspartate transaminase and alanine transaminase, the oxidative stress markers and an increase of the glutathione and superoxide dismutase 77.32% and 101.02%, the antioxidants produced by the host, comparable to CCl4 treated cells.
The antioxidant activity of fig and artichoke was attributed to the existence of different phenolic metabolites that act synergistically.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics by Youssef FS1, Labib RM1, Eldahshan OA1, Singab ANB. (PubMed)
(2) Antioxidant activity and cytotoxicity of Jerusalem artichoke tubers and leaves extract on HaCaT and BJ fibroblast cells by Nizioł-Łukaszewska Z1, Furman-Toczek D1, Zagórska-Dziok M. (PubMed)