Saturday, 13 April 2019

Phytochemical 3,3'-Diindolylmethane Protects the Process of Hematopoiesis

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the protection of hematopoiesis with no side effects, according to studies.

Hematopoiesis is the process by which blood cells are formed, including the formation of all of the cellular components of blood and blood plasma.

1. Red blood cells with a function to transport oxygen and hemoglobin to the body.

2. White blood cells that form parts of the immune system, including
* T cells and B cells, that fight virus, and tumors. 

* Neutrophils that fight bacteria and fungi.

* Eosinophils that fight some parasites and initiate an inflammatory response.

* Basophils that release the histamines necessary for the inflammatory response.

* Macrophages, the first line of immune response in the acute phase of infection.

3. Platelets (thrombocytes) for coagulation.

Diseases of the bone marrow, spleen, lymph nodes, and thymus may affect the process of hematopoiesis, leading to various diseases of the hematopoietic system.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding a natural compound for the treatment of hematopoietic injury, researchers examined 3,3'-Diindolylmethane (DIM) effect on the hematopoietic system injury induced by total body irradiation (TBI) that leads to the generation of intracellular reactive oxygen species (ROS) and DNA damage.

In TBI-induced lethality mice, DIM ameliorated TBI-induced hematopoietic injury by inhibiting the production of ROS production in hematopoietic stem cells (HSCs).

Furthermore, DIM improved the bone marrow (BM) HSC frequency, hematopoietic progenitor cell (HPC) clonogenic function, and multilineage engraftment after transplantation in tested mice.

Additional analysis of DIM anti hematopoietic injury, researchers found that DIM promotes the genes associated with the increased production of antioxidant enzymes (nuclear factor erythroid 2-related factor 2 (Nrf2)) in the hematopoietic stem cells (HSCs) and decreased the production of free radicals (NADPH oxidase 4 (NOX4)).

DIM also protected the cells against apoptosis by increasing the expression of the anti-apoptotic protein (Bcl-2) and decreasing expression of the pro-apoptotic protein (Bax).

The results strongly suggested that DIM attenuates TBI-induced hematopoietic injury through the inhibition of both the oxidative stress in HSCs and hematopoietic cell apoptosis.

Dr. Lu L and colleagues wrote in the final report, "DIM protected BM hematopoietic cells against ionizing radiation and led to increased clonogenicity in vitro. Therefore, DIM has the potential to be used as an effective radioprotectant to ameliorate TBI-induced hematopoietic injury".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the protection and treatment of hematopoietic injury, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) 3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice by Lu L1, Dong J2, Li D2, Zhang J2, Fan S. (PubMed)

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