Renal fibrosis is a condition of kidney scars caused by improper healing of the kidney in regenerating damaged cells after an injury.
On finding a natural compound for the treatment of renal fibrosis with no side effects, researchers in the renal disease team led by the Renmin Hospital of Wuhan University examined 3,3'-Diindolylmethane (DIM), a natural acid condensation extracted from cruciferous plants, anti-fibrotic effects.
DIM suppressed local fibroblast proliferation, a process that begins with a reaction to the clot associated with scar developing, observed by the scar contraction with the level of α-smooth muscle actin (α-SMA) and vimentin in scar tissue.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renalfibroblast activation in vivo and in vitro by Xia ZE1, Xi JL2, Shi L. (PubMed)