Wednesday, 3 October 2018

Herbal Arnica and Its' Bioactive Sesquiterpene Lactones That Block Cancer Cells of Leukemia From Spreading, Scientists Reveal

By Kyle J. Norton

Arnica may have substantial and sustainable effect in reducing risk, progression, and treatment of leukemia, some scientists suggested.

The results of these report were conducted by numbers of respectable institutes, including the Chonnam National University and Westfälische Wilhelms-Universität and published online on the database of medical literature.

Leukemia is a medical condition characterized by cells growth uncontrollable and disorderly produced by the body's blood-forming tissues, including the bone marrow and the lymphatic system. In most cases, it is the result of abnormal white blood cells, which don't function properly.

According to the reliable statistic, approximately every 3 minutes one person in the United States (US) is diagnosed with leukemia. New cases of leukemia, lymphoma, and myeloma are expected to account for 10 percent of 1,735,350 new cancer cases diagnosed in the US in 2018.

The exact causes of leukemia are unknown. However, certain risk factors including smoking, mutation gene inherited from parents such as Down syndrome. blood disorders such as myelodysplastic syndrome are associated with the increased risk of the disease.

Some researchers also suggested that people who have previous treatment for cancer with chemotherapy or radiation are at higher risk of cancer development.

Most common symptoms of leukemia include fever or chills,  persistent fatigue and weakness frequent or severe infections due to dysfunction of the immune system caused by immature white blood cells produced. 

Some patients may also experience symptoms of unattended weigh loss,  swelling lymph nodes,... and enlarged liver or spleen.

If you experience some of the above symptoms, please check with your doctor to rule out the possibility.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.

Leukemia is a chronic condition characterized by high numbers of abnormal white blood cells in the bone marrow.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the investigation of the effect of helenalin, a bioactive chemical compound isolated from Arnica on human promyelocytic leukemia HL-60 cell line, researchers found that application of the compound exerts a significant effect in induced HL-60 cell differentiation through the expression of granulocytes, white blood cells with secretory granules in its cytoplasm, at a concentration-dependent manner.

Further analysis, injection of helenalin inhibited HL-60 through activating the protein kinase C (PKC) inhibitor with a function to act as ruboxistaurin in signaling molecules that link to multiple cellular processes of cancer.

Moreover, researchers also found that helenalin also inhibits HL-60 proliferation through activating the extracellular signal-regulated kinase (ERK) inhibitors which are used in some cancer therapy in controlling diverse tumor cellular processes such as proliferation, survival, and motility.

Protein kinase C (PKC) is a family of protein kinase enzymes with function in controlling the expression of other proteins through certain mechanisms.

Additional differentiation also suggested that helenalin induced expression of protein kinase C (PKC) inhibitors without interfering with PKC activity and protein level of PKC beta I and PKC beta II isoforms activities which have been found to promote progression of human cancer.

Interestingly, helenalin also inhibited HL-60 through increasing levels of protein kinase R-like endoplasmic reticulum kinase (PERK) with function in triggering cancer cell death in a concentration-dependent manner.

Finally, researchers also indicated that the inhibition of HL-60 by helenalin are also carried out through ameliorating levels of NF-kappa, with aberrant activity in enabling leukemia cells to evade apoptosis and stimulate proliferation.

High levels of NF-κB has been detected in most of the patients with acute myeloid leukemia (AML).

These result postulated that helenalin isolated from Arnica inhibits the expression of human promyelocytic leukemia HL-60 cell line through many different pathways involved several aspects in tumor cellular differentiation.

More importantly, in the different aspect of the study, Dr. Dirsch VM and colleagues found that sesquiterpene lactones also exerted a significant cytotoxic effect in triggering leukemia cell apoptosis.

According to cell morphology, four compounds found in sesquiterpene lactones, including ambrosin, alantolactone, hymenin and helenalin induced apoptosis of Jurkat leukemia T cells, individually, through inducing apoptosis of nuclei and the outer surface of the cell membrane.

Taken together, Arnica and its bioactive sesquiterpene lactones, particularly helenalin may be used to ameliorate the risk, progression, and treatment of  Leukemia.

However, additional data collection on large example size and multi-centers studies performed with human consumption of herbal arnica or its' bioactive sesquiterpene lactones during the course of the disease will be necessary to complete the picture of garlic anti-leukemia possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone by Kim SH1, Oh SM, Kim TS. (PubMed)
(2) Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis by Dirsch VM, Stuppner H, Vollmar AM. (PubMed)

1 comment:

  1. Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide