Intake of coffee daily and regularly has a profound effect in reduced inflammatory expression, a renowned institute study suggested.
Inflammation is a natural reaction of the immune system in protecting the body against foreign invasion and after injury and damage to tissues or organs.
Most cases of acute inflammation are systemic immune response occurred when the body's white blood cells release chemicals into the blood or injured tissues to protect your body against infection caused by the foreign invasion through the stimulated production of inflammatory cytokines.
Under normal condition, cytokines IL-6 and IL10 exert anti-inflammatory activity against inflammation by inhibition of tumor necrosis factor (TNF), and IL-1 production by macrophages. However, in the case of bodily injury or damage, cytokines IL-6 and IL10 can switch promptly to pro-inflammatory cytokines for maximum protection of the body against infection,
However, in some cases, overproduction of pro-inflammatory cytokines over a prolonged period of time not only can cause to damage to cells and tissue of the infectious site but also can injure the nearby healthy cells and tissue, leading to abnormal tissue healing such as scars and a high degree of cell death.
Conventional medicine such as prescription NSAIDs and pain relief, such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve) may be effective in reducing pain and acute inflammation. However, they can increase the risk of heart attack and stroke and side effects of dizziness, drowsiness, headache, nausea, constipation, and seizures.
Researchers do not the exact cause of chronic inflammation, but they do know that it is caused by the: failure of the immune system to completely eliminate substances that cause an acute inflammation or immune system mistakenly a normal healthy tissue as a pathogen and attacks them.
Coffee has become a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
In the analysis to clarify the beneficial effects of caffeine consumption in human health and behaviour, the mechanisms against pathophysiology of neurodegenerative diseases, researchers at the joint study led by the University of Coimbra found that coffee caffeine reduced the onset and progression of neurodegenerative diseases, through controlling microglia(cells in the brain and spinal cord) reactivity and neuroinflammation.
Dr. Madeira MH, the lead researchers said, "caffeine controls microglia-mediated neuroinflammatory response associated with the majority of neurodegenerative conditions".
Interestingly, the study to evaluate the Spent coffee grounds (SCG) anti-inflammatory effects conducted lead by the Universidad Autónoma de Querétaro, suggested that the efficacy of SCG in reduced risk of inflammatory is probably associated to high contents of antioxidant such as phenolic compounds, and fermentability by the human gut flora, in regulating the pro-inflammatory expressions, even with roasting effect in reduced total phenolic contents of SCG in influenced colonic fermentation.
After considering all other factors, the study strongly insisted, "Spent coffee grounds (SCG), rich in dietary fiber can be fermented by colon microbiota producing short-chain fatty acids (SCFAs) with the ability to prevent inflammation".
More importantly, in the examined numbers of prospective and retrospective cohort studies, coffee consumption against relative risk of developing major depressive disorder in humans, caffeine and phytochemicals such as chlorogenic acid, ferulic acid and caffeic acid, all important constituents of coffee, showed to attenuated risk of depression through mediated inflammation, in vitro and in vivo.
Dr. Hall S, the lead author said, "The ability of bioactive coffee constituents to modulate the parameters of neuroinflammation has been shown with caffeine having strong antioxidant properties in vitro, chlorogenic acid and the caffeic acid having strong anti-inflammatory and antioxidant properties in vitro and ferulic acid having activities in vivo animal models of depression".
Taking all together, there is no doubt that coffee intake daily and regularly has a significant effect in reduced risk of inflammation through overexpression of the presence of bioactive constituents.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammationin Neurodegenerative Diseases by Madeira MH1, Boia R1, Ambrósio AF2, Santiago AR2. (PubMed)
(2) Spent coffee grounds, an innovative source of colonic fermentable compounds, inhibit inflammatory mediators in vitro by López-Barrera DM1, Vázquez-Sánchez K1, Loarca-Piña MG1, Campos-Vega R2. (PubMed)