Chaste tree berry is found to exhibit a significant anti-cancer activity, a recent study by renowned study advised.
Cancer is a class of diseases characterized by cells growing and multiplying disordered and uncontrollable way in our body.
In the late stage, the cancer cell may travel away from the originated site to infect other healthy tissue and organs.
As to today, researchers do not what cause cancers. Neither they understand why? people who have similar health conditions, one group is susceptible to cancer onset, while other does not.
However, researchers do not know that certain prevalent risk factors such as aging, excessive alcohol consumption, chemical carcinogenic substances, an unhealthy diet with high amount saturated and trans fats, sugars,... and salts are associated to the onset of the disease.
Some researchers also suggested that people who have chronic inflammation, using hormone replacement and immunosuppression medicine are also at a higher risk of cancers development.
Certain infectious agents including hepatitis A, B, C and bacterium Helicobacter pylori infection also have the potential to induce a change of DNA of the healthy cells, a major cause of cancers,
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the Tianjin Institute for Biomedicinal Research, in the evaluated the apoptosis-inducing effect of chaste tree berry, using observation under light microscope, flow cytometric analysis and agarose gel electrophoresis, vitexicarpin, a flavonoid found in chaste tree berry significantly inhibited proliferation of human cancer cells lines A2780(human ovarian carcinoma), HCT-15(human, colon, colorectal adenocarcinoma), HT-1080(fibrosarcoma cell line) and K562(Human chronic myeloid leukemia cells), depending to the concentration.
Dr. Wang HY the lead researcher in the study said, "Vitexicarpin induces apoptosis.... via mitochondria (in regulated cell metabolism)-controlled apoptotic pathway".
In support of the above analysis, the crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits also exerted a strong cytotoxic effects against cancer cell lines of human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.
The inhibition of the extract is attributed to the effect on cell death through apoptosis and increased intracellular oxidation in the tumor cells.
Other researchers suggested that the cytotoxic effects of Chaste tree berry may be involved in various aspects, including the JNK (apoptosis) pathway. as indicated in the new native lignan VB6 study.
Taking together, there is no doubt, that chaste tree berry may be considered as a valuable chemotherapeutic agent for treatment of various types of cancer, depending on further evaluation.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].[Article in Chinese] by Wang HY1, Cai B, Cui CB, Zhang DY, Yang BF. (PubMed)
(2) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(3) Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway by Zhou J1, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y. (PubMed)