Appendicitis is defined as a condition of inflammation of
Appendix. It is classified as an emergency, in many required the
removal of the appendix. If burst, or perforate, spilling infectious
materials into the abdominal cavity can be life threatening.
Treatment in Herbal medicine perspective
1. Phaseolus angularis Wight (adzuki bean)
Phaseolus angularis Wight (adzuki bean) is an ethnopharmacologically
well-known folk medicine that is prescribed for infection, edema, and inflammation of the joints, appendix,
kidney and bladder in Korea, China and Japan. According to the study by
the, Pa-EE dose-dependently suppressed the release of PGE(2) and NO in
LPS-,
Poly(I:C)-, and pam3CSK-activated macrophages. Phaseolus angularis
ethanol extract (Pa-EE) strongly
down-regulated LPS-induced mRNA expression of inducible NO synthase
(iNOS) and cyclooxygenase (COX)-2. Interestingly, Pa-EE markedly
inhibited NF-κB, activator protein (AP)-1, and cAMP response element
binding protein (CREB) activation; further, according to direct kinase
assays and immunoblot analyses, Pa-EE blocked the activation of the
upstream signaling molecules spleen tyrosine kinase (Syk), p38, and
transforming growth factor β-activated kinase 1 (TAK1). Finally, orally
administered Pa-EE clearly ameliorated EtOH/HCl-induced gastritis in
mice(37).
2. Cinnamomum cassia
Cinnamomum cassia Blume (Aceraceae) has been traditionally used to treat
various inflammatory diseases such as gastritis. According to the study
by the Sungkyunkwan University, 95% ethanol extract (Cc-EE) of
Cinnamomum cassia exerts strong anti-inflammatory activity by
suppressing
Src/Syk-mediated NF-κB activation, which contributes to its major
ethno-pharmacological role as an anti-gastritis remedy. Future work will
be focused on determining whether the extract can be further developed
as an anti-inflammatory drug(38).
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Sources
(37) http://www.ncbi.nlm.nih.gov/pubmed/21821108
(38) http://www.ncbi.nlm.nih.gov/pubmed/22155395
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