Andrographis paniculata
is also known as Andrographis is a herbaceous plant, genus
Andrographis, belonging to the family Acanthaceae, native to India and
Sri Lanka. It has been used in traditional Siddha and Ayurvedic in
treating the common cold, flu, upper respiratory infections, infectious
diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes,
leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Rheumatoid Arthritis
Rheumatoid Arthritis is defined a chronic disorder as a result of
inflammation, affecting mostly the flexible (synovial) joints and
tissues and organs in the body. The disease affects more women than in
men and generally occurs after the ages of 40 and diminishes the quality
of life of many elders.
The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter
taste, other ingredients includediterpene lactones, such as:
neoandrographolide, andrographiside,
14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz.,
oroxylin, wogonin, andrographidines A, B, C, D, E, F.
The benefits
Andrographis
paniculata (AP) possesses
anti-inflammatory effects, as a result of its main constituent
andrographolide proposed as alternative in the treatment of autoimmune
disease, according to the study of Tablets (Paractin) made of an extract
of A. paniculata (30% total
andrographolides) were administered three times a day for 14 weeks,
after a 2-week washout period to 60 patients with active RA. In the
study of osteoclast formation, AP suppressed RANKL-induced
osteoclastogenesis through attenuating NF-κB
and ERK/MAPK signalling pathways in vitro, thus preventing bone loss in
vivo. of which may be a potential therapeutic natural compound for the
treatment of osteoclast-related bone diseases. Others in the study of he
pseudo-tumoral expansion of fibroblast-like synoviocytes which is a hallmark
of rheumatoid arthritis (RA), showed that andrographolide exerts anti-growth and pro-apoptotic effects on RAFLSs,
thus may have therapeutic potential for the treatment of RA. by induced cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.
The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating
of glycogen and cholesterol in the testis, and increased activities of
lactate dehydrogenase in testis and alkaline phosphatase in testis and
ventral prostate, thus reducing the risk of fertility.
2.
People with gallbladder disease may want to consult with their doctor
before using because of the herb stimulating gallbladder contraction
effect.
3. Etc.
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References
1. Andrographis paniculata, http://essenherb.com/plant1.html
2. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis
symptoms: a prospective randomized placebo-controlled trial, by Burgos
RA, Hancke JL, Bertoglio JC, Aguirre V, Arriagada S, Calvo M, Cáceres
DD. (PubMed)
3. Andrographolide induces cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. by Yan J, Chen Y, He C, Yang ZZ, Lü C, Chen XS.(PubMed)
4. Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
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