Sunday, 3 March 2019

Herbal Andrographis, the Best Herbal Remedy for Malaria with No Side Effects

By Kyle J. Norton

Scientists may have found a herbal medicine for the treatment of malaria with no side effects, according to studies.

Malaria is a mosquito-borne infectious disease caused by parasitic protozoans.

People who are using the immune suppressive drug, having a weakened the immune system and infected by the HIV virus are more likely to experience severe effects of the infection.
Some researchers suggested that Women who are pregnant are at an increased risk of malaria infection.

Dr. Ebako Ndip Takem the lead scientist in the concern of malaria in pregnancy, wrote, "Pregnant women have a higher risk of malaria compared to non-pregnant women" 

And "Maternal risk factors for malaria in pregnancy (MiP) include low maternal age, low parity, and low gestational age. The main effects of MIP include maternal anemia, low birth weight (LBW), preterm delivery and increased infant and maternal mortality".

Most common symptoms of the disease are shaking chills alternated with a high fever. profuse sweating. a headache, nausea. vomiting. abdominal pain and diarrhea.

In the Western world, malaria is almost nonexistent due to sanitation and mosquitos spray. However, the disease is most prevalent in the countryside of the third world countries due to living conditions and medication.

Due to the widespread of malaria in the third, the World Health Organization has set a goal for the prevention and treatment of malaria, including the develop products that will provide: efficacy against drug-resistant strains of Plasmodium falciparum, potential for intermittent treatments (infants and pregnancy), safety in small children (less than 6 months old), safety in pregnancy, efficacy against Plasmodium vivax (including radical cure), efficacy against severe malaria, and transmission-blocking treatment.

Andrographis paniculata is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The herbal plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

In the urgency of finding a natural anti-malaria herbal medicine with low cost for the treatment of malaria in the third world, researchers evaluated the effect of extracts of Andrographis paniculata (AP) and Hedyotis corymbosa (HC).

Methanolic extracts of the plants were tested in vitro on choloroquine sensitive (MRC-pf-20) and resistant (MRC-pf-303) strains of Plasmodium falciparum.

The 50% inhibitory concentration (IC50) of AP (7.2 microg/ml) was found better compared to those of the HC at a dose of 10.8 microg/ml).

Combination of these two herbal drugs showed substantial enhancements to their anti-malarial activity.

Increased in vivo potency was also observed with the combination of plant extracts, compared to the individual extracts and curcumin.

In-depth analysis of the plant extracts, researchers found the plant extracts inhibit the ring stage of the parasite and did not show any in vivo toxicity, whether they are used in isolation or in combination.

Dr. Mishra K, the lead scientist wrote on the final report, "Both these two plant extracts in combination with curcumin could be an effective, alternative source of herbal anti-malarial drugs".

Additionally, the investigation of the adulticidal and repellent activities of different solvent leaf extracts of Eclipta alba (E. alba) and Andrographis paniculata (A. paniculata) against malarial vector, Anopheles stephensi (An. stephensi) by comparing the adulticidal efficacy of the crude leaf extracts of E. alba and A. paniculata with five different solvents like benzene, hexane, ethyl acetate, methanol and chloroform was tested against the five to six day old adult female mosquitoes of An. stephensi.

Among the tested solvents the methanol extract showed a maximum efficacy compared to others. The LC(50) and LC(90) values of E. alba and A. paniculata against adults of An. stephensi were 150.36, 130.19 ppm and 285.22, 244.16 ppm.

According to the chi-square values, the methanol extract of A. paniculata produced maximum repellency against An. stephensi.

Dr. Govindarajan M and colleagues in the research team said, "the crude extract ..... A. paniculata was an excellent potential for controlling An. stephensi mosquitoes".

Taken altogether, herbal Andrographis may be considered a functional remedy for the prevention and treatment of malaria for the third world countries where conventional medicne are expensive and hard to find with no side effects, pending to the confirmation of a large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin by Mishra K, Dash AP, Swain BK, Dey N.(PubMed)
(2) Mosquito adulticidal and repellent activities of botanical extracts against malarial vector, Anopheles stephensi Liston (Diptera: Culicidae) by Govindarajan M, Sivakumar R.(PubMed)
(3) Malaria in Pregnancy by Ebako Ndip Takem1 and Umberto D’Alessandro. (PMC)

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