Ginger, the Potential Anti-Septic Functional Remedy, Scientists Show

By Kyle J. Norton

On seeking a natural therapy with no side effects, scientists may have found a kitchen pungent spice for the prevention and treatment of sepsis, according to studies.

Sepsis is a medical condition caused by the body over-response to infection by releasing a large number of chemicals into the bloodstream, leading to chemicals imbalance that can damage multiple organ systems.

Most common sites of infection leading to sepsis are found in older patients with the lungs, urinary tract, tummy (abdomen) and pelvis.

The causes of sepsis, in most cases, are involved in people with a weakened immune system or a severe infection that allow the inflammation to spread to the entire body.

Sepsis can be life-threatening due to the interruption of blood flow to the body caused by inflammation in the induction of blood vessel constriction.

The risk factors of sepsis include any medical conditions which can lead to a weakened immune system, such as AIDs and chemotherapy, the very young (immature immune system) and old (weakened immune system due to aging), pregnancy and diabetes.

Most common symptoms of sepsis are associated with symptoms of reduced blood flow, including, a decrease in mental ability,  problems breathing. abnormal heart functions, fall blood pressure, fall in body temperature. unconsciousness.

If your child or yourself experience some of the above symptoms, please call the emergency services right the way.

Some researchers suggested that people who are obese may have a negative implication on the immune system in fighting against infection that can cause sepsis. 

Dr. A S Kolyva, the lead scientists said, "Sepsis is one of the most important causes of mortality in the developed world, where almost two-thirds of the population suffer from obesity".

And, "Obesity is associated with elevated TNFα adipose tissue production and increased oxidative stress biomarkers, promoting the proinflammatory response in septic patients".

These results strongly suggested that obesity may induce overexpression of proinflammatory cytokines that not only initiates the onset of sepsis and also increases the potential negative impact on the outcome.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural compound or food for the treatment of sepsis, researchers investigated the effects of a phenolic alkanone isolated from ginger in various pharmacological activities, including sepsis.

Injection of ginger exerted a modulatory effect on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.

The modulation of ginger was attributed to the suppression of the production of the inflammatory cytokines such as TNF-α and IL-6 and the activation of proteins associated with inflammation induced by HMGB.

High mobility group box 1 (HMGB1) is a protein associated with the immune protective response by restoring the endothelial cells which line the interior surface of blood vessels and lymphatic vessels integrity.

Furthermore, injection of ginger also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in the initiation of inflammation in mice.

Moreover, in vivo, ginger inhibited the lymphopoiesis (CLP) in stimulating the production of the release of HMGB1, sepsis-related mortality, and tissue injury.

In order to reveal more information about ginger antisepsis activity, researchers examined zingerone (ZGR), a bioactive compound isolated from ginger on TGFBIp-mediated septic responses.

Similar to that of the above, ZGR reduced the TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice.

Injection of ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury.

Dr. Min G, the lead scientist, after taking into account co and confounders wrote in the final report, "ZGR could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway".

Taken altogether, ginger may be considered a functional remedy for the treatment of sepsis, pending to the confirmation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice by Lee W1, Ku SK2, Bae JS. (PubMed)
(2) Suppressive effects of zingerone on TGFBIp-mediated septic responses by Min G1, Ku SK2, Lee T3, Bae JS4. (PubMed)
(3) The role of obesity in the immune response during sepsis by A S Kolyva,1 V Zolota,2 D Mpatsoulis,2 G Skroubis,3 E E Solomou,4 I G Habeos,5S F Assimakopoulos,1 N Goutzourelas,6 D Kouretas,6 and C A Gogos. (PMC).