Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor (SSRIs)
are a types of antidepressant medications to treat depression and
certain neurological disorders, including obsessive-compulsive
disorder, panic disorder (PD), generalized anxiety
disorder, post traumatic stress disorder (PTSD), and social anxiety
disorder (SAD), etc..
SSRI discontinuation syndrome is defined as a condition of a
syndrome as a result of interruption, reduced doses or discontinuation
of any anti depressant medication, including SSRI (selective serotonin
re-uptake inhibitor) and serotonin–norepinephrine reuptake inhibitor
(SNRI), researchers showed that The SSRI discontinuation syndrome is a characteristic selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome
appears to exist. It is usually mild, commences within 1 week of
stopping treatment, resolves spontaneously within 3 weeks, and consists
of diverse physical and psychological symptoms, the commonest being
dizziness, nausea, lethargy and headache. SSRI reinstatement leads to resolution within 48 h(1).
Treatments
A. In conventional medicine perspective
A.1. Graduation of doses and later discontinued
There are
suggestion that symptoms may occur even if the SSRI dose is tapered
gradually. In half of 50 reported cases, an attempt was made to taper
the SSRI, although details concerning the duration and rapidity of taper
were not provided consistently. At this point, it is unclear whether
tapering SSRIs will reduce the risk nor is it clear whether we should
advocate the routine taper of SSRIs when stopping treatment. The only
known effective treatment is the re-introduction of the SSRI which is
associated with rapid resolution of symptoms. Unfortunately, the
syndrome tends to recur in approximately 75% of patients when the same
SSRI is later discontinued(12).
A.2. Treatment depends on symptom severity
If symptoms of SSRI discontinuation are so severe, or do not respond to
symptom management, patients may be necessary to reinstate the
antidepressants and withdrawn the medication slowly as mention above.
Others suggested to switch to a long half-life medication at a
relatively low dose and then stop taking SSRI altogether(20).
A.3. Treating the symptoms
Certain medication may be prescribed to treat the symptoms of Selective
serotonin re-uptake inhibitor (SSRI) discontinuation syndrome. Please
consult with your doctor.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/10958258
(12) http://www.circlemedhealthcare.com/ssri.pdf
(20) http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291099-1166%28199806%2913:6%3C421::AID-GPS774%3E3.0.CO;2-Y/abstract;jsessionid=3C78BDD20E857C086A4C305B9880784E.d02t02
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