Nephritis is defined as a condition of inflammation of the nephrons in the kidneys.
Interstitial nephritis (Tubulo-interstitial nephritis)
Interstitial nephritis is defined as a condition of inflammation of the
spaces between renal tubules, affecting the interstitium of the kidneys
and kidney function in wast removal.
Treatment
F.1. In conventional medicine perspective
1. Acute tubulointerstitial nephritis
In the study to evaluate the controversial effects of steroids in acute tubulointerstitial nephritis (ATIN), showed that steroid treated (StG) patients had a greater degree of improvement in their renal
function; however there was no correlation between the degree of
improvement in eGFR and delay in starting steroids. PPIs were second
commonest implicated drug category among drug induced cases(13).
2. Chronic tubulointerstitial nephritis
Chronic tubulointerstitial nephritis has no cure. Many patients may
require dialysis. In younger patient, kidney transplant may be the only
choice.
F.2. In herbal medicine perspective
1. Soy
In the study to evaluate the effects of soy
protein isolate (SPI) on severe kidney damage in deoxycorticosterone
acetate (DOCA) salt-treated obese Zucker rats, researchers at the Food
Science Research Institute, Fuji Oil Company Ltd., Izumisano-shi, showed
that that consecutive treatment of SPI protects against renal
dysfunction, particularly tubulointerstitial nephritis, in DOCA salt-treated obese Zucker rats(14).
2. Flaxseed
In the study to determine if flaxseed would also modify clinical course and renal pathology in the Han:SPRD-cy rat, showed that Flaxseed ameliorates Han:SPRD-cy rat polycystic kidney disease through moderation of the associated chronic interstitial nephritis.
The diet alters renal content of polyunsaturated fatty acids in a
manner that may promote the formation of less inflammatory classes of
renal prostanoids(15).
3. Etc.
F.3. In traditional Chinese medicine perspective
1. Traditional Chinese medicine with immunosuppressant
In an experimental study combined on traditional Chinese medicine with immunosuppressant for treatment and prevention of tubular interstitial nephritism researchers at the Department
of Nephrology, First Affiliated Hospital, showed that the infiltration
of cells was inhibited in the "Chinese herbs combined
with prednisone" group, the infiltration of cells, TGF-beta expression
and interstitial fibrosis were all inhibited in the cyclophosphamide and prednisone" group. But in the prednisone group, interstitial
fibrosis was not inhibited. These data suggest that the combined use of
Chinese herbs, immunosuppressant and prednisone can inhibit the interstitial cell infiltration and prevent the interstitial fibrosis in diffuse proliferative glomerulonephritis(16).
2. Astragali Radix and Angelicae Sinensis Radix (AS-IV)with ferulic acid
Other researchers suggested that AS-IV synergizes with FA to alleviate
renal tubulointerstitial fibrosis; this was associated with inhibition
of tubular
epithelial-mesenchymal transdifferentiation (EMT) and fibroblast
activation, as well as an increase in NO production in the kidney(17).
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Sources
(12) http://www.ncbi.nlm.nih.gov/pubmed/14655203
(13) http://www.ncbi.nlm.nih.gov/pubmed/22817666
(14) http://www.ncbi.nlm.nih.gov/pubmed/22553937
(15) http://www.ncbi.nlm.nih.gov/pubmed/9987066
(16) http://www.ncbi.nlm.nih.gov/pubmed/12515139
(17) http://www.ncbi.nlm.nih.gov/pubmed/21232035
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