Tuesday, 3 December 2013

Duodenitis - The Symptoms

Duodenitis is defined as a condition of inflammation in the lining of the duodenum, the first section of the small intestine.

I. Symptoms
1. Abdominal pain
In a report of Thirty nine children with recurrent abdominal pain aged between 5.5 and 12 years, underwent endoscopic duodenal biopsy. Duodenal inflammation was graded by the duodenitis scale of Whitehead et al (grade 0, 1, 2, and 3). In 13 out of 39 patients (33%) definite signs of inflammation were found (grade 2 and 3). Intestinal permeability to 51Cr-EDTA in patients with duodenitis (grade 1, 2, and 3) was significantly higher (4.42 (1.73)%) than in patients with normal (grade 0) duodenal biopsy appearances (3.3 (0.9)%)(1).

2. Loss of appetite, epigastric pain and weight loss
Parasitic infection cause of  Duodenitis can lead to loss of appetite and weight loss, according to the study of An extremely uncommon case of parasitic infection presenting as eosinophilic ascites in a young patient, by thye research team at the GATA Haydarpasa Training Hospital(2).

3. Other symptoms
In the study of over a 15 month period, 124 referred patients were evaluated in a prospective cohort analysis with a standardised investigation including duodenal biopsies and aspirate, blood tests and faecal parasite and calprotectin tests. Recovered subjects were recruited for symptom analysis, researchers at the Haukeland University Hospital, found that There were significant associations between persistent Giardia positivity, microscopic duodenal inflammation and a positive calprotectin test. In patients with persisting symptoms after metronidazole treated Giardia infection we commonly found chronic Giardia infection and microscopic duodenal inflammation, especially in illness duration less than 7 months. Both these findings subsided over time. Increasingly, investigations could not determine a definite cause for the persistent symptoms. The very long-term post-giardiasis diarrhoea, bloating, nausea and abdominal pain documented here need further study(3). 

4. Etc.
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(1) http://www.ncbi.nlm.nih.gov/pubmed/2125404
(2) http://www.ncbi.nlm.nih.gov/pubmed/21552435
(3) http://www.ncbi.nlm.nih.gov/pubmed/17964658
(3a) http://www.ncbi.nlm.nih.gov/pubmed/18158085   

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