Nephritis is defined as a condition of inflammation of the nephrons in the kidneys.
Interstitial nephritis (Tubulo-interstitial nephritis)
Interstitial nephritis is defined as a condition of inflammation of the
spaces between renal tubules, affecting the interstitium of the kidneys
and kidney function in wast removal.
Causes and Risk factors
1. In the study of The outcome of acute interstitial nephritis: risk factors for the transition from acute to chronic interstitial nephritis, researchers at the Department of Nephrology, MHH, Hannover, Germany, in determination of risk factors for the development of chronic renal insufficiency, and thus, the transition from acute to chronic interstitial nephritis, showed that acute interstitial nephritis was found in 6.5% of all biopsies (64 patients with 68 episodes of acute interstitial nephritis);
it was infection-induced in 10%, idiopathic in 4%, and drug-induced in
85% of the cases (antibiotics in 13 cases, analgesics in 17,
non-steroidal anti-inflammatory drugs (NSAIDs) in 16, diuretics in 5,
and various other drugs in 7). Renal insufficiency was reversible in 69%
and permanent in 31% (12% partially reversible, 19% irreversible). The
infection-induced and idiopathic types of acute interstitial nephritis were always reversible. Drug-related acute interstitial nephritis
caused permanent renal insufficiency in 36% with a maximum of 56% in
NSAID-induced cases. In drug-induced cases, intake of the suspected drug
for more than a month prior to diagnosis caused permanent renal
insufficiency in 88% and interstitial granuloma in 31%(2).
2. Impaired potassium and magnesium homeostasis and urinary losses are associated with the increased risk of acute tubulo-interstitial nephritis(3)
3. Hypercalcemia is a
life-threatening disorder and is related primarily to neoplastic
diseases and primary and secondary hyperparathyroidism and associated to
the risk of Interstitial nephritis(4).
4. Allergic effect
A severe generalized multisystem allergic reaction occurred in a 16-month-old infant following the use of trimethoprim-sulfamethoxazole. Acute interstitial nephritis
developed three weeks following the onset of this reaction and resolved
after three months. This is the first description of this renal
toxicity with TMP-SMX in a child(4a).
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(2) http://www.ncbi.nlm.nih.gov/pubmed/11020015
(3) http://www.ncbi.nlm.nih.gov/pubmed/4058627
(4) http://www.ncbi.nlm.nih.gov/pubmed/19356379
(4a) http://www.ncbi.nlm.nih.gov/pubmed/7149348
No comments:
Post a Comment