The ketogenic diet (KD) is defined as a high-fat, low-protein, low-carbohydrate diet,
used commonly as a treatment for patients with difficult-to-control
epilepsy. In a study conducted by Department of Neurology, Epilepsy
Centre Kempenhaeghe(1) of 15 adults treated with the classical diet or MCT diet,
during a follow-up period of 1 year, assessment of seizure frequency,
seizure severity, tolerability, cognitive performance, mood and quality
of life (QOL) were reported. By Analyzing the study months separately,
researchers found that a seizure reduction of ≥50% in 26.6% of the
patients during at least 1month of treatment. Common side-effects were
gastrointestinal disorders, loss of weight
and fatigue. There was a considerable, non-significant improvement
found in mood and QOL scores. Improvements were independent of reduction
in seizure frequency, indicating that the effects of the KD reach
further than seizure control.
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(1) "The ketogenic diet
as a treatment option in adults with chronic refractory epilepsy:
Efficacy and tolerability in clinical practice" by Lambrechts DA,
Wielders LH, Aldenkamp AP, Kessels FG, de Kinderen RJ, Majoie MJ., posted in PubMed
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