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Saturday, 21 December 2013

Low-dose hCG administration enhance preganacy with hypothalamic amenorrhea due to weight loss

Human chorionic gonadotropin or human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy, made by the developing embryo after conception.
In the evaluation of a 24-year-old woman with weight loss-related amenorrhea underwent ovulation induction and intracytoplasmic sperm injection (ICSI). Administration of exogenous gonadotropins was ineffective in ovulation induction. Supplementation with low-dose hCG in order to increase luteinizing hormone (LH) activity in the late follicular phase produced late folliculogenesis and steroidogenesis, and ovulation was then successfully induced(1)

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(1) "Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss" by Tsutsumi R, Fujimoto A, Osuga Y, Harada M, Takemura Y, Koizumi M, Yano T, Taketani Y.