In a random study of groups designated as control diet (CON), control diet with exercise (CONEx), high-protein (HP), or high-protein
with exercise (HPEx). Free-living women from the Guelph community
conducted by University of Guelph, Guelph. Actual diets consumed by the
subjects contained ratios of carbohydrate to protein
of 3.0:1, 2.7:1, 1.5:1, and 0.96:1 for the CON, CONEx, HP, and HPEx
groups, respectively. Cardiovascular fitness improved in both exercise
groups. There were no changes in resting energy expenditure. No adverse
events were reported. Significant changes in blood lipids included
decreased total cholesterol in the HP and CONEx groups, decreased
low-density lipoprotein cholesterol in the HP group only, and decreased
blood triglycerides in the HPEx group only. High-density lipoprotein cholesterol, fasting blood glucose, and fasting insulin levels were unaltered by diet or exercise. A high-protein diet was superior to a low-fat, high-carbohydrate diet either alone or when combined with an aerobic/resistance-training program in promoting weight loss
and nitrogen balance, while similarly improving body composition and
risk factors for the Metabolic Syndrome in overweight and obese Canadian
women.
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(1) "A randomized trial of a hypocaloric high-protein diet, with and without exercise, on weight loss, fitness, and markers of the Metabolic Syndrome in overweight and obese women" by Meckling KA, Sherfey R., posted in Pubmed
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