Saturday, 21 December 2013

Conjugated linoleic acid and Obesity control

Conjugated linoleic acids (CLA) are a family of over 28 isomers of linoleic acid found abundantly in the meat and dairy products. As obesity is associated with high blood cholesterol and high risk for developing diabetes and cardiovascular disease. Therefore, management of body weight and obesity are increasingly considered as an important approach to maintaining healthy cholesterol profiles and reducing cardiovascular risk. In the review of a few studies in mice fed CLA mixtures with different ratios of c9t11 and t10c12 isomers have indicated that the t10c12 isomer CLA may be the active form of CLA affecting weight gain and fat deposition. Inductions of leptin reduction and insulin resistance are the adverse effects of CLA observed in only mice, but the effect on Pid is inconsistent. A number of human studies suggest that CLA supplementation has no effect on body weight and insulin sensitivity. Although it is suggested that the t10c12 CLA is the antiadipogenic isomer of CLA in humans, the effects of CLA on fat deposition are marginal and more equivocal as compared to results observed in animal studies(1)

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(1) "Conjugated linoleic acid and obesity control: efficacy and mechanisms" by Wang YW, Jones PJ.