Conjugated linoleic acids (CLA) are a family of over 28 isomers of
linoleic acid found abundantly in the meat and dairy products. As
obesity is associated with high blood cholesterol and high risk for
developing diabetes and cardiovascular disease. Therefore, management of
body weight and obesity are increasingly considered as an important
approach to maintaining healthy cholesterol profiles and reducing
cardiovascular risk. In the review of a few studies in mice fed CLA
mixtures with different ratios of c9t11 and t10c12 isomers have
indicated that the t10c12 isomer CLA may be the active form of CLA
affecting weight gain and fat deposition. Inductions of leptin reduction
and insulin resistance are the adverse effects of CLA observed in only
mice, but the effect on Pid is inconsistent. A number of human studies
suggest that CLA supplementation has no effect on body weight and
insulin sensitivity. Although it is suggested that the t10c12 CLA is the
antiadipogenic isomer of CLA in humans, the effects of CLA on fat
deposition are marginal and more equivocal as compared to results
observed in animal studies(1)
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(1) "Conjugated linoleic acid and obesity control: efficacy and mechanisms" by Wang YW, Jones PJ.
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