Lycopene Protects the Kidney and Heart Cells Against Nephrotoxicity and Cardiotoxicity

By Kyle J. Norton

Nephrotoxicity is toxicity in the kidneys associated with reduced function of the kidney due to toxic chemicals, and medications.

The kidneys are essential bean shape organ of our body, located just below the rib cage, one on each side of your spine.

Kidneys play a critical role in filtering blood with billions of glomeruli by separating the cells of blood from plasma and reabsorb back substances, and secret waste such as urea and ammonium are stored into pelvis then into the ureter to the bladder.

Furthermore, kidneys also process the functions that regulate electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin, etc. 

In the urinary system, the kidney also reabsorbed back substances into the blood, while others waste, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.

Most common symptoms of nephrotoxicity decreased urine output, fluid retention, causing swelling in your legs, ankles or feet, weakness, fatigue, and irregular heartbeat.

In severe cases, patients may also experience symptoms of shortness of breath, and confusion.

Cardiotoxicity, on the other hand, is toxicity in the heart associated with reduced heart muscle capacity in the blood circulation due to toxic chemicals, and medications.

The heart, a four-chambered, hollow muscle and double acting pump that is located in the chest between the lungs is a muscular organ in the human body processed the function that pumps blood through the blood vessels of the circulatory system to nourish the body and assist in the removal of metabolic wastes.

According to the statistic provided by the American Heart Foundation, on average, an American dies of CVD every 38 seconds. In 2016, cardiovascular diseases cause the death of 2,303 deaths each day, in the US.

Compared to nephrotoxicity, patients with cardiotoxicity may have symptoms of fatigue, shortness of breath on exertion, worsening to shortness of breath at rest, discomfort lying on your back and welling of the ankles.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On finding a potential compound which processes cardio and nephroprotective effects, researchers examined the effects of lycopene against the toxic effects of Aflatoxin B1(AFB1) exposure in kidney and heart of experimental rats.

A total of 42 healthy three-month-old male Wistar-Albino rats were randomly divided into six experimental groups including 7 rats in each as following control group, lycopene (5 mg/kg/day, orally for 15 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) group, AFB1 (1.5 mg/kg/day, orally for 3 days) group, AFB1 (0.5 mg/kg/day, orally for 7 days) + lycopene (5 mg/kg/day, orally for 15 days) group and AFB1(1.5 mg/kg/day, orally for 3 days) + lycopene (5 mg/kg/day, orally for 15 days) group.

Compared to AFB1 and according to the tested analysis, the elevated levels of malondialdehyde (MDA) levels associated with oxidative stress markers were significantly decreased in the lycopene treatment group.

The reduced levels of antioxidant enzymes in the AFB1 group such as glutathione (GSH), glutathione-S-transferase (GST), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glucose-6-phosphate-dehydrogenase (G6PD) activities were increased substantially in kidney and heart tissues upon the injection of lycopene.

Furthermore, the non-enzymatic antioxidant system in AFB treated rats that cause the rise of oxidative stress in the rat kidney and heart were also inhibited by administration of lycopene.

Moreover, lycopene also inhibited the increased urea, creatinine levels, and reduced-sodium concentrations in plasma of AFB1 treated rats.

Based on the findings, researchers said, "There was lycopene showed protection against AF induced nephrotoxicity and cardiotoxicity".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of osteoporotic fractures, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene by Yilmaz S1, Kaya E2, Karaca A2, Karatas O. (PubMed)
(2) Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessment by Anjos Ferreira AL1, Russell RM, Rocha N, Placido Ladeira MS, Favero Salvadori DM, Oliveira Nascimento MC, Matsui M, Carvalho FA, Tang G, Matsubara LS, Matsubara BB. (PubMed)

Bromelain Speeds Up Healing of Ecchymosis

By Kyle J. Norton

Ecchymosis is a discoloration of the skin caused by the bleeding underneath the skin, typically in bruising.

Most cases of ecchymosis are results in which the blood vessels near the surface of the skin burst, particularly in the impact of an injury.

In other words, ecchymosis is associated with blood vessel leaks, and the blood is accumulated under the skin.

The discoloring of the skin is also involved in the clotting factors, that stop the bleeding so that the tissue starts healing.

The progression of ecchymosis is gone through a certain stage from red or purple to black or blue

 to brown and to yellow.

Certain medications have been found to induce ecchymosis including:

* Blood thinners, such as aspirin or warfarin 

*Antibiotics such as cephalexin, cefaclor, and cefuroxime-axetil can cause ecchymosis by inducing low platelet count

* Corticosteroids 

According to the study from the University College Hospital, easy bruising tended to be older (61 vs 52 yrs), on higher daily dosages (1,388 vs 1,067 micrograms), particularly in the long term inhaled corticosteroids users.

Most cases of ecchymosis usually heal on their own within two to three weeks.  Most common medications used for the treatment of ecchymosis are pain relievers.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential compound for the treatment of ecchymosis, researchers examined the effects of bromelain on ecchymosis postprocedure unwanted effects.

In the reconfirm the effect of bromelain used internationally by physicians on limit ecchymosis secondary to cosmetic, laser, and surgical skin procedures, researchers reviewed the published literature and provide evidence-based recommendations on bromelain for prevention and treatment of postprocedure ecchymosis.

The search on the computerized bibliographic databases Medline, EMBASE, Scopus, and CINAHL on March 23, 2015, identified 7 clinical trials that study the effect of oral bromelain in the prevention and/or treatment of postprocedure ecchymosis compared to no studies that use topical bromelain for the treatment of ecchymosis.

Based on the results, 5 out of 7 randomized controlled trials reported improvement postprocedure ecchymosis in the bromelain-treated group.

Taken altogether, bromelain may be considered a remedy for the treatment of postprocedure ecchymosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature by Ho D1, Jagdeo J, Waldorf HA. (PubMed)
(2) Easy bruising as a side-effect of inhaled corticosteroids by Mak VH1, Melchor R, Spiro SG. (PubMed)

Herbal Turmeric Kills Kidney Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a group of diseases associated with cells growing and multiplying disordered and uncontrollable in the tissue of the specific organ.

Over time, the alternation of the cell DNA on the surface on the inner lining tissue may become progressively worse by penetrating into deeper layers of the infected organs.

At the advanced stage, cells of most invasive tumors can spread to other organs in the body via lymph or blood.

The kidney is an essential organ of our body, that not only plays a critical role in the urinary system, but also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin.

In the urinary system, kidney filters blood with billions of glomeruli by separating the cells of blood from plasma. 

As the plasma passing into the tubules, some necessary substances are reabsorbed back into the blood, while others waste, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.

Renal cell carcinoma is the most common type of kidney cancer caused by malignant cells of the lining of the tubules in the kidney. Renal cell carcinoma tends first to spread to the lung, but it may also spread to lymph nodes and other organs as well.

Because of less nervous in the kidney and location, patients in the early stage of renal cell carcinoma are asymptomatic. In other words, kidney tumor can grow without causing any pain and discomfort. Most common symptoms of kidney cancer are
* Abdominal pain that is dull and constant lasting for hours.

*Back pain that is dull and constant lasting for hours.

* Blood in the urine is a result of break off of the tumor in the tubules.

* Unintentional weight loss

Any intentional weight loss of over 10% is one of the most common symptoms of cancer.

*  Flank pain is a sensation of discomfort, distress, or agony in around the back and side of the abdomen.

* Swelling and enlargement of the abdomen happens to approximate 15% of all cases of renal cell carcinoma. 

*Anemia
If cancer has affected the function of erythropoietin in the production of hemoglobin.

* Varicocele enlargement is a result of the blockage of the left (right) testicular vein by tumor invasion of the left (right) renal vein.

*Hypertension is a result of secretion of renin by the tumor.

If you experience some of the aforementioned symptoms persistently, please check with your doctor to rule out the possibility of kidney cancer

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of renal cell carcinoma, researchers examined the combined treatment with natural compounds and NVP-BEZ235 in human renal carcinoma Caki cells.

Where NVP-BEZ235 is an inhibitor of signaling pathways associated with the development of kidney tumors.

According to the tested analysis, curcumin markedly induced apoptosis in NVP-BEZ235-treated cells.

Co-treatment with curcumin and NVP-BEZ235 led to the down-regulation of Mcl-1 protein expression Involved in the regulation of apoptosis and survival of cancer cells but not mRNA expression in tested cells.

Furthermore, the co-administration also inhibited the protein associated with the anti-apoptotic activity of Bcl-2.

Interestingly, in colon cancer cell line analysis, Combined treatment with NVP-BEZ235 and curcumin reduced Bcl-2 expression in wild-type p53 HCT116 human colon carcinoma cells but not p53-null HCT116 cells.

In skin cell perspectively, NVP-BEZ235 combined with curcumin did not have a synergistic effect on normal human skin fibroblasts and normal human mesangial cells.

Based on the findings, researchers suggested that curcumin combined with the NVP-BEZ235 induced human renal carcinoma Caki cells apoptosis by regulating the protein associated with anti-apoptosis accompanied by blocking the activation of proliferative signaling pathways.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of kidney cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability by Seo BR1, Min KJ1, Cho IJ2, Kim SC2, Kwon TK. (PubMed)
(2) Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells by Li H1, Jin X, Zhang Z, Xing Y, Kong X. (PubMed)
(3) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton

The 31 Health Benefits of Cranberry, According to Studies

By Kyle J. Norton

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

1. Cranberry Inhibits the Symptoms and Improves Quality of Life In Women with Urinary Tract Infections
2. Cranberry Extract Kills Nasopharyngeal Cancer Cell in Vitro
3.  Cranberry, the Natural Cancer Anti Colon Cancer Remedy in Vivo
4. Cranberry Processes the Potent Anticancer Activity in Vitro
5. Cranberry Kills Ovarian Cancer Cells In Vitro
6. Cranberry promotes postprandial blood glucose management
7. Healthy Food Cranberry, the Best in the Promotion of Oral Health
8. Cranberry Inhibits the Risk and Symptoms of Bladder Cystitis
9. Healthy Food Cranberry, the Natural Antioxidant
10.  Healthy Food Cranberry Protects the Heart Against Cardiovascular Toxicity
11. Cranberry, the Potent Free Radical Scavenger
12. Cranberry, the Anti Urinary Tract Infection Healthy Food
13. Healthy Food Cranberry, the Natural Anti-Inflammatory Remedy
14. Cranberry Inhibits Neurodegenerative Diseases in Vitro
15. Cranberry Protects the Integrity of Bladder Cells Against Bladder Cancer
16. Cranberry Arrests Breast Cancer Cells in Vitro
17. Cranberry Inhibits the Risk and Onset of Oral Cancer
18. Cranberry, Inhibits the Progression of Chronic Kidney Disease (CKD)
19. Cranberry Protects the Body Against Bacterial Infection
20. Berry Extract (Cranberry) Inhibits β-Amyloid Aggregation 
21. Healthy Food Cranberry Inhibits the Risk and Onset of Cancer
22. Cranberry, May be Potent Against Psychosis
23. Cranberry, the Anti Candida Albicans Overgrowth Natural Remedy
24. Cranberry Juice improves Quality of Life in Patients with Rheumatoid Arthritis
25. Cranberry Decreases Homocysteine and Increases Adiponectin Levels in Patients with Metabolic Syndrome
26. Cranberry Protects the Bladder Against Radiation Cystitis.in Prostate Cancer Patients
27. Cranberry Does Not Improve Urinary Infection in Patients with. Multiple Sclerosis
28. Cranberry in the Prevention of Advanced Glycation (AD) Expression
29. Cranberry Improves Symptoms of Neuro-Psychology
30. Cranberry Inhibits Parameters Associated with the Onset of Colitis
31. Cranberry Has No Effects on Urinary Disorders in MS patients

To Be Continued

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

The 56 Amazing Health Benefits of Bromelain, According to Scientists

By Kyle J. Norton


Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc..
1. Bromelain Found in Pineapple Suppresses the Symptoms and Onset of Osteoarthritis (OA)
2. Bromelain, the Potential and Natural Treatment of Arthritis with No Side Effects
3. Bromelain Modulates Your Immune System Against Allergic Symptoms
4. Bromelain Speeds Up Skin Healing with No Side Effects
5. Bromelain, the Best Natural Remedy for Reducing Pain and Swelling
6. Bromelain Inhibited Metabolic Factors Associated with Cardiovascular Diseases Developing
7. Bromelain Protects the Inner Lining of Colon Against Colitis
8. Bromelain, the Natural Prevention and Treatment of Inflammatory Bowel Disease (IBD)
9. Bromelain Kills Ovarian Cancer Cells in Vitro
10. Bromelain, Stops Colon Cancer Developing in Vitro and Vivo
11. Bromelain Protects the tissues Against the Onset of Chronic Wound Healing
12. Bromelain Suppresses Rheumatoid Arthritis in Vivo
13. Bromelain Inhibits the Parameters Associated with The Onset of Alzheimer's disease
14. Bromelain Inhibits Knee Pain in Human Trials
15. Bromelain Inhibits Cancer Initiation and Progression in Vitro and Vivo
16. Bromelain Suppresses Osteoarthritis (OA) Similar to Those of Diclofenac with No Side Effects
17. Bromelain Blocks the Onset of Endometriosis
18. Bromelain, Suppresses the Risk and Onset of Colitis
19. Bromelain, a Natural Treatment of Pelvic Pain with No Side Effects
20. Bromelain Promotes and Removes Eschar In Burn Wounds, Human Trials Show
21. Bromelain Protects the Cardiac Muscle in Blood Circulation
22. Bromelain Protects the Cell DNA Against Genotoxicity
23. Bromelain Exerts Anti Inflammatory Effects on Airway Inflammation In Vivo
24. Bromelain, the Anti Acute Inflammation Whole Foods
25. Bromelain Blocks the Onset and progression of Invasive Glioma in Vitro
26. Bromelain Suppresses Rheumatic Disease with No Side Effects
27. Bromelain, Inhibits Melanoma in Vitro and Vivo
28. Bromelain Promotes Anti Inflammatory Activity Against Allergic Asthma
29. Bromelain Kills Mammary Cancer Cells in Vitro
30. Bromelain Improves the Neurological Status in Post Acute Infarction
31. Bromelain Modulates the Immune Function Against Allergic Airway Disease
32. Bromelain Inhibits the Risk of Skin Cancer In Vitro
33. Bromelain, the Potential Prevention and Treatment of Flu Influenza
34. Bromelain, the Natural Prevention and Treatment of Chronic Rhinosinusitis (RS) With No Side Effects
35. Bromelain, The Natural Prevention and Treatment of Edema
36. Bromelain Kills Gastrointestinal Cancer Cells in Vitro
37. Bromelain Protects the Joints Against Osteoarthritis
38. Bromelain, a Natural Prevention and Treatment of Chronic Constipation
39. . Bromelin Inhibits Symptoms in Patients with Functional Dyspepsia
40. Bromelain Kills Breast Cancer Cells in Vitro
41. Bromelain Modulated the Immune System Against the Development of Diseases
42. Bromelain Kills Leukemia Cancer Cells
43. Bromelain, the Natural Prevention and Treatment of Inflammatory Bowel Disease (IBD)
44. Bromelain, the Natural Anti Blood Coagulation Remedy
45. Bromelain, the Anti-Obesity Functional Remedy
46. Bromelain, the Best Antioxidants
47. Bromelain Enhances the Efficacy of Chemo Drug and Reduced Adverse Effects
48. Bromelain Normalizes the Enzymes In Blood Clots
49. Bromelain Ameliorates Endometrial Pain
50. Bromelain, Processes Cytotoxic Property Against Peritoneal Mesothelioma
51. Bromelain Modulates the Immune Function Against Allergic Airway Disease (AAD)
52. Bromelain Inhibits the Onset of Acute Diarrhea in Vivo
53. Bromelain, the Potential Treatment of Chronic Rhinosinusitis
54. Bromelain, Protects the Skin Cell Against Cancer Developing
55. Bromelain Promotes Enzyme and Evokes Antibodies. Against the Progression of Lung Cancer
56. Bromelain Improves the Symptoms and Quality of Life in Patients with Cystic Fibrosis

and counting

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Healthy Food Onion Processes Anti Hypertensive Effects

By Kyle J. Norton

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure is a condition associated with abnormally high blood pressure in the arteries.

High blood pressure is also a condition of a cluster of metabolic syndrome involved in the risk of cardiovascular disease and diabetes.

If the blood pressure stays high over time, it not can damage the heart muscle but also the body in many ways.

According to the statistic from the CDC, 1 of 3 U.S. adults or about 75 million people is living with high blood pressure. Unfortunately, only about half (54%) of these people have their high blood pressure under control.

There is no single cause of high blood pressure, 

* Most unpreventable risk factors are family history, age, gender, ethnicity, and chronic kidney disease.

* Most preventable high blood pressure risk factors are physical inactivity, overweight or obese, unhealthy diet, smoking, and excessive alcohol drinking.

However, most people with some of the risk factors have never developed hypertension

Some researchers suggested that the rise of obesity associated with the promotion of a high-fat diet over the past decades may be the major influence on the onset of high blood pressure.

Dr. Wilde DW, the lead scientist said, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".

And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca(2+) current density and alteration of channel kinetics in the vascular smooth muscle membrane".

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potent ingredient for the prevention of hypertension, researchers evaluated the effect of aqueous extract of garlic, white onion, and purple onion on subjects with blood pressure.

Elevated levels of an angiotensin-converting enzyme associated with the high blood pressure were inhibited by the aqueous extract of garlic, purple onion, and white onion in a concentration-dependent manner (0-4 mg/ml).

Additional differentiation also suggested that purple onion (IC50 = 0.59 mg/ml) had higher inhibitory effect on angiotensin-converting enzyme comapred to those of white onion (IC50 = 0.66 mg/ml) and purple onion (IC50 = 0.96 mg/ml).

Furthermore, all aqueous extracts showed a significant activity to scavenge 2,2- diphenyl-1-picrylhydrazyl (DPPH*) free radical and reduce Fe3+ to Fe2+ in a dose-dependent manner.

Based on the findings, researchers concluded, "a possible mechanism by which garlic, white onion, and purple onion exert... antihypertensive properties could be through the inhibitory effect on ACE,.. coupled with their ability to prevent lipid peroxidation in the pancreas and heart, which justify their strong antioxidant properties".

Taken altogether, onion used alone or combined with garlic may be considered a remedy for the prevention and treatment of hypertension, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory Effect of Garlic, Purple Onion, and White Onion on Key Enzymes Linked with Type 2 Diabetes and Hypertension by Oboh G1, Ademiluyi AO1, Agunloye OM1, Ademosun AO1, Ogunsakin BG. (PubMed)
(2) High-fat diet elevates blood pressure and cerebrovascular muscle Ca(2+) current by Wilde DW1, Massey KD, Walker GK, Vollmer A, Grekin RJ. (PubMed)

Phytochemical Lycopene Ameliorates Neuro-Oxidative Stress in Aging Degenerative Diseases

By Kyle J. Norton

Oxidative stress in a condition caused by overexpression of free radicals and the depletion of antioxidant enzymes found in the host.

In other words, oxidative stress is a result of a long-term imbalance of the ratio of free radicals and antioxidants.

Antioxidants can be either produced by the liver or consumptions of antioxidant-rich fruits and vegetables.

Antioxidants are stable molecules that protect our body against free radical oxidation.

Free radicals are any chemical compounds which have an oxygen molecule that can become free radical after chemical interaction in the body

Most healthy individuals can produce enough amounts of antioxidant enzymes endogenously to counter the bombards of free radicals.

However, for people with a weakened immune system such as elderly and immature immune system may require the injection of antioxidants from the outside sources, particularly from the second metabolites.

Epidemiologically, oxidative stress has been found to promote a number of age-related conditions, including cardiovascular diseases CVDs, chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer.

Not all free radicals are bad in the moderate amounts, our body needs limit levels of some free radicals to function better, including lower blood pressure, relax blood vessels to move blood, such as nitric oxide NO.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

On findings a phytochemical compound for the treatment of diseases associated with oxidative stress, scientists examined the effects of lycopene (LYC), a carotenoid pigment, on oxidative stress-induced cognitive defects.

According to the behavioral tests, chronic LYC supplementation (50 mg/kg body weight per day) alleviated d-galactose-induced CD-1 male mice cognitive impairments.

Furthermore, LYC ameliorated histopathological neuron damage and restored brain-derived levels of neurotrophic factor (BDNF), a neurotransmitter modulator associated with neuronal survival and growth, serves in the hippocampus of mice.

Moreover, LYC also significantly stimulated the production of antioxidant enzymes such as HO-1 and NQO-1 and reduced levels of inflammatory cytokines such as IL-1β and TNF-α in the d-galactose-treated mice serum.

The Immunohistochemical assay also suggested that LYC significantly restored the expression of glial cells inflammatory makers Iba-1 and GFAP that responses to proinflammatory expression.

More importantly, LYC protected the neuronal against oxidative damage through activation of Nrf2 signaling in the regulation of anti-inflammatory gene expression and inactivation of NF-κB translocation associated with pro-inflammatory expression in an H2O2-induced SH-SY5Y cell model.

Dr. Zhao B, the lead scientist wrote, "LYC could ameliorate oxidative stress-induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-κB transcriptional pathway".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation by Yu L, Wang W, Pang W, Xiao Z, Jiang Y, Hong Y. (PubMed)
(2) Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X. (PubMed)