Bromelain Blocks the Onset of Endometriosis

By Kyle J. Norton

Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else instead of the inside of the uterus.

More precisely, on the last stage of the menstrual cycle, instead of a layer of endometriosis lining on the inside of the uterus expelled, known as menstruation blood, some of the endometriosis tissues grow somewhere in the body.

Most endometriosis tissues do not travel far. Most cases of endometriosis are diagnosed within the pelvic region, on the lining of peritoneum, in the ovaries, and on the surface of the uterus's an outside wall, however, the condition can also be found anywhere in the body such as well as fallopian tubes, the cervix, the vagina, and even the vulva.

Believe it or not, about

* 20% of reproductive age women with endometriosis present without symptoms.

*55% of women who have developed the new onset of severe menstrual cramps.

* 25% of women with sub-fertility (less fertile than a normal couple)

Endometriosis can be classified into different stages, depending on the severity of the disease

* Minimal stage:
 Commonly they are found on the top surface, of  the inside wall of uterus, ligaments, and ovary with a few in numbers.

* Mild stage:
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.

* Moderate stage:
Many implants, endometrial cysts present, affecting ovary function, causing scar tissues and adhesion are also present.

* Severe stage:
Intensive peritoneal implants, large endometromas present and dense adhesion.
Each woman experiences differently to endometriosis. Some women may have extensive endometrial tissues in their body but feel little or no pain at all, compared to other women in the early stage of endometriosis with excessive pain.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the treatment of endometriosis, researchers evaluated the efficacy of an association of N-acetyl cysteine, alpha-lipoic acid, and bromelain (NAC/LA/Br) in vivo murine model and in vitro human endometriotic endothelial cells (EECs) and on endothelial cells isolated from the normal uterus (UtMECs.

In endometrial cells EECs preincubated with NAC/LA/Br, levels of pro-inflammatory cytokines associated with TNF-α were significant reduced observed by lower expression of the inflammatory "marker" VCAM1.

On human endometriotic cysts intraperitoneally into SCID mice, NAC/LA/Br exerted a strong apoptotic activity against EECs without affecting the endothelial cells isolated from the normal uterus (UtMECs).

Furthermore, compared to untreated mice, mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size.

Based on the findings, researchers said, "these dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis".

Moreover, in order to reveal more information about NAC/LA/Br on symptoms of endometriosis, researchers examined the effect of N-acetyl cysteine, alpha lipoic acid, and bromelain on endometriosis- pelvic pain.

In a total, 398 patients with a mean age of 34.6 ± 7.2 years, treatment of the combination of N-acetyl cysteine, alpha lipoic acid, and bromelain for 6 months showed a significant improvement in endometriosis-associated pelvic pain compared to the baseline.

More precisely, compared to the baseline of 92.7% of the patients had pain intensity > 4 on the visual analog scale (VAS); treatment of NAC/LA/Br at 3 months decreased the percentage of patients to 87.2% (p = 0.074) and at 6 months to 82.7%, respectively.

Dr. Lete I, the lead scientist said, "Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics".

Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of endometriosis and endometrial symptoms, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study by Lete I1, Mendoza N2, de la Viuda E3, Carmona F. (PubMed)
(2) The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis by Agostinis C1, Zorzet S2, De Leo R1, Zauli G1, De Seta F3, Bulla R. (PubMed)
(3) Endometriosis part I - Definition, Stages, Symptoms, Causes, and Effects Of Endometriosis by Kyle J. Norton