Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.
At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending to the location of cancer.
Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organ, leading to secondary metastasis through the circulation of blood and fluids.
According to the statistic provided by the American Cancer Society, in the US 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are results of cancer.
The research team at the University of Oxford on finding a potential compound for the treatment of cancer with no side effects examined the bromelain capacity against cancers in the past and present studies.
Evidence derived from clinical observations, mouse- and cell-based models suggested that bromelain, a 95%-mixture of proteases acts systemically, affecting multiple cellular and molecular targets.
NPs induced cellular uptake of MCF-7, HeLa and Caco-2 cells monolayer by several folds compared to free BL.
Furthermore, in Swiss albino mice, NPs injection not only reduced the tumor burden of Ehrlich ascites carcinoma (EAC) but also increased their life-span (160.0 ± 5.8%) compared to free BL.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives by Chobotova K1, Vernallis AB, Majid FA. (PubMed)
(2) Anti-cancer activity of bromelain nanoparticles by oral administration by Bhatnagar P, Patnaik S, Srivastava AK, Mudiam MK, Shukla Y, Panda AK, Pant AB, Kumar P, Gupta KC. (PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)