Friday, 24 May 2019

Bromelain Inhibits Knee Pain in Human Trials

By Kyle J. Norton

Knee pain or pain on the knee is a common complaint of people of all ages, particularly in the older population.

Causes of knee pain may be a result of ruptured ligament or torn cartilage and medical conditions such as arthritis, gout, and infections.

Acute knee pain is a condition that recovers itself in a short period of time.

Chronic knee pain is a medical condition that lasts more than 3 months. 

Compared to the acute knee pain, the most common causes of chronic knee pain are low-grade inflammation caused by repeated overuse or injury of the knee, that lead to damaged cartilage under the kneecap.

Chronic knee pain is also associated with patients with gout caused by the buildup of uric acid.

According to the statistics, approximately, 100 million Americans suffer from chronic pain. Knee pain is the second most common cause of chronic pain

In the gender perspective, between 15 and 20% of all men are afflicted with knee pain, compared to the overall prevalence of knee pain of roughly 20% in women.

Most common symptoms of knee pain are swelling and stiffness, particularly in the morning, redness and warmth to the touch, weakness, and instability and Inability to fully straighten the knee.

Conventionally, the immediate treatment for acute knee pain caused by occupation is rest, ice, and compression and pain relievers and anti-inflammatory drugs are prescribed to ease inflammation and pain.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for pain relief, researchers examined the effects of bromelain on patients with acute knee pain of fewer than 3 months duration in healthy adults.

Participants in the open, dose-ranging postal study were recruited through newspaper and magazine articles and received either 200 mg or 400 mg per day for one month.

According to the tested assays and questionnaire returned by 77 subjects who completed the study, both treatment groups showed a significant improvement of all WOMAC symptom dimension scores, particularly, in total symptom score.

Compared to the low dose intervention, treatment with 400 mg bromelain per day demonstrated a better of total symptom score (P = 0.036) and the stiffness (P = 0.026) and physical function (P = 0.021).

However, compared to the baseline, overall psychological well-being was significantly improved in both groups.

Based on the findings, researchers wrote, "We conclude that bromelain may be effective in ameliorating physical symptoms and improving general well-being in otherwise healthy adults suffering from mild knee pain in a dose-dependent manner".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of acute knee pain, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults by Walker AF1, Bundy R, Hicks SM, Middleton RW. (PubMed)

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