Wednesday, 9 October 2019

Cranberry Has No Effects on Urinary Disorders in Multiple Sclerosis (MS) Patients

By Kyle J. Norton

Infection is an inflammatory condition caused by a microbial invasion on body tissues

Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has been found to make them resistant to antibiotics.

Most common symptoms of bacterial infection include redness and heat, swelling, fever, pain at the site of infection.

Urinary tract infection (UTIs) mostly occurred in women is an infection that affects the bladder and urethra caused mostly by bacterial strains Escherichia coli (E. coli), commonly found in the gastrointestinal (GI) tract.

UTIs have been found to limit the function of the bladder and induce kidney infection.

Most common symptoms of urinary infection are persistent urge to urinate, urinary burning sensation, cloudy urine, and smelly urine.

In severe cases, patients may also experience symptoms of blood in the urine and bladder and pelvic pain.

Most common risk factors of urinary tract infection are gender, females are more like to have UTI comapred to males, sexual activity, use of birth control, and menopausal women.

Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system) casued by the immune system attacks the protective sheath (myelin) that covers nerve fibers.

MS causes communication problems between the brain and the rest of the body.

SHARON BEGLEY in examing the genetic preposition involved in MS wrote, " A newly discovered genetic mutation gives people who carry it a whopping 70 percent chance of developing multiple sclerosis, potentially opening the way toward new therapies for a debilitating neurological disorder whose ultimate cause has stumped researchers for decades".

The author continued, "The 70 percent chance of developing MS compares to a 0.1 percent risk in the general population, and the 100 or so previously known genetic variants increase the chance of MS to only about 0.3 percent at most, with no single gene packing much of a punch".

In other words, people having certain genes inherited from the parent are at the substantial risk of MS developing comapred to people who do not.

According to the statistics, in 2010/2011, approximately 93,500 Canadians were diagnosed with the disease or 290 cases per 100,000 population. Believe it or not, MS is the most prevalent in Canada comapred to other parts of the world.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the prevention of urinary infections, researchers examined the effect of cranberry extract (CE) in multiple sclerosis (MS) patients suffering from urinary disorders.

The prospective, double-blind study included a total of 171 adult MS outpatients with urinary disorders presenting at eight centers received either to cranberry extract ((36 mg proanthocyanidins per day) or matching placebo for 1-year.

According to the results of follow up, the were no difference between cranberry and placebo).
In other words, there was no difference in time to first symptomatic UTI distribution across 1 year, with an estimated hazard ratio of 0.99, 95% CI [0.61, 1.60] (p = 0.97).

Furthermore, the econdary endpoints and tolerance also did not differ between groups.

Based on the findings, researchers aid, "Taking cranberry extract versus placebo twice a day did not prevent UTI occurrence in MS patients with urinary disorders".

Taken altogether, cranberry can not be considered a remedy for the prevention and treatment of urinary disorders in MS patients, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Cranberry versus placebo in the prevention of urinary infections in multiple sclerosis: a multicenter, randomized, placebo-controlled, double-blind trial by Gallien P1, Amarenco G2, Benoit N3, Bonniaud V4, Donzé C5, Kerdraon J6, de Seze M7, Denys P8, Renault A9, Naudet F10, Reymann JM. (PubMed)
(2) Discovery of multiple sclerosis gene could inspire new therapies — if it’s right by By SHARON BEGLEY

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