Bromelain Suppresses Rheumatic Disease with No Side Effects

By Kyle J. Norton

Rheumatism or rheumatic disorder is a group of medical conditions associated with chronic, often intermittent pain that affects the joints and/or connective tissue.

Most common symptoms of rheumatism are joint pain, loss of motion in a joint or joints and low-grade inflammation that causes swelling, redness, and warmth in a joint or affected area.

Most common types of rheumatism are 

* Osteoarthritis (OA), a form of arthritis, is a condition of aging-induced wear and tears on a joint, affecting over 25 million people in the US.

* Rheumatoid arthritis (RA) is a chronic disorder associated with the inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. RA affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.

* Gout mostly affected one joint is an acute and recurrent condition of arthritis caused by uric acid building up in the blood, inducing joint inflammation.

* Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

*  Polymalagia arthritis is a condition of inflammatory rheumatic disease which causes pain, stiffness, and tenderness in large muscles, including muscles shoulders and pelvic girdle.

* Lupus is an autoimmune disease, caused by the immune system overreaction that attacks its tissues, causing inflammation, swelling, pain, and damage.

* Juvenile idiopathic arthritis (JIA) is the type of arthritis that occurs in children with symptoms of  persistent joint swelling, pain, and stiffness

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the treatment of arthritis, researchers examined the effect of an oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) in the treatment of rheumatic diseases.

The retrospective cohort study with parallel groups was to compare the efficacy of enzyme combination to those of nonsteroidal anti-inflammatory drugs (NSAID).

According to the data of 3326 patients treated for rheumatic diseases in which 2139 patients were treated either only with OE or only with NSAID, between January 1993 and the end of March 1995  registered by 380 physicians, both treatments yielded similar results.

However, there was a 50% higher success rate in OE than for NSAID, compared the initial and treatment situations.

OE also scored higher stratification according to propensity score.

Furthermore, treatment duration more than 30 days and joint diseases or fibromyalgias in age over 50 years, pre-treatment with antirheumatic or analgesic drugs showed significant negative effects in patients response compared to those of OE.

Additionally, according to the aforementioned and other indicators associated with freedom from symptoms, OE exerted an expectation compared to NSAID treatment.

The results strongly support the use of the oral enzyme-combination product (OE; Phlogenzym, containing trypsin, bromelain, and rutin) for the treatment of rheumatic disease instead of NSAIDs

Dr. Wittenborg A, after taking other factors into account, wrote in the final report, "OE were well tolerated showing much less adverse events when compared with conventional doses of NSAID".

Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of rheumatic disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review].[Article in German] by Heyll U1, Münnich U, Senger V. (PubMed)
(2) [Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation].[Article in German] by Wittenborg A1, Bock PR, Hanisch J, Saller R, Schneider B. (PubMed)
(3) General Health by Kyle J. Norton