Bromelain, Protects the Skin Cell Against Cancer Developing

By Kyle J. Norton

Skin cancer is a medical condition caused by irregular cell growth in the skin due to the alternation of cell DNA.

Skin cancer is one most common type of cancer in the US. According to the statistics provided by the CDC, skin cancer affects 1 in 5 American and non-epithelial skin cancers represent 7% of skin cancers tracked by central cancer registries.

In 2012, more than 5.4 million cases of nonmelanoma skin cancer were diagnosed worldwide compared to only 3.3 million cases in the U.S. 

The 5-year relative survival rate of basal cell carcinoma(BCC) and squamous cell carcinoma (SCC) is 95%.

Squamous cell carcinoma of the skin is one of the most common forms of squamous cells skin cancer developed in the middle and outer layer of the skin.

Although there are a number of conditions that can cause squamous cells skin cancer. However, in the US, the most squamous cell carcinomas of the skin are associated with a prolonged exposure to ultraviolet (UV) radiation, either from sunlight or from tanning beds.

Dr. Faurschou A, the lead scientist said in vivo, "(although) the amount of UVB penetrating the epidermis and reaching the bulge cells is very low, which questions if these cells suffer sufficient DNA damage to transform into cancer stem cells".

And, "UV-induced SCC of mice originates from cells of the hair follicle, presumably the bulge stem cells, indicating that ultraviolet radiation penetrates epidermis sufficiently to cause irreversible DNA damage in cells located beneath the epidermis".

Most common symptoms of squamous cells skin cancer include firm, red nodule, flat sore with a scaly crust, a rough, scaly patch on your lip, a red sore or rough patch inside the mouth.

If you have experienced some skin symptoms that can not be healed in a short period of time, you may have squamous cells skin cancer. Please make sure that you check with your doctor to rule out the possibility.

Depending on the size of the skin tumor, the small size of the localized tumor can be completely removed with relatively minor surgery or occasionally with a topical medication.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential compound for the treatment of squamous cell cancer, researchers examined the bromelain, obtained from pineapple, anti-cancer effects in vitro, against human epidermoid carcinoma-A431.

In vitro, administration of bromelain exhibited a reduction in proliferation of both these cell-lines and suppressed their potential from anchorage-independent growth, a hallmark of carcinogenesis.

Injection of bromelain also suppressed the proteins associated with the production of proinflammatory cascade closely allied to cancer developing.

Additionally, bromelain inhibited the proliferation of cells by inducing the depletion of intracellular glutathione and generation of reactive-oxygen-species followed by induced cell death by mitochondrial membrane depolarization. 

Furthermore, bromelain induced cell death through the expression of proteins associated with cell death programming and pro-apoptosis observed by cell cycle arrest.

In other words, bromelain protects the integrity and viability of the squamous cell against the alternation of cell DNA against the onset of cancer.

Based on the finding, researchers said, "Bromelain afforded substantial anti-cancer potential in these settings; hence we suggest it as a potential prospect for anti-cancer agent besides only an additive in chemotherapy".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of squamous cell skin cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis by Bhui K1, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y. (PubMed)
(2) Characterization of the placental alkaline phosphatase-like (Nagao) isozyme on the surface of A431 human epidermoid carcinoma cells by Jemmerson R, Shah N, Takeya M, Fishman WH. (PubMed)
(3) Squamous cell carcinoma induced by ultraviolet radiation originates from cells of the hair follicle in mice by Faurschou A1, Haedersdal M, Poulsen T, Wulf HC. (PubMed)