Cranberry Protects the Bladder Against Radiation Cystitis in Prostate Cancer Patients

By Kyle J. Norton

Cystitis is a medical condition associated with inflammation of the bladder, leading to the symptoms of bladder irritation and swelling. Women are prone to the condition compared to men.

Most common cause of the bladder cystitis is a bacterial infection involved in a urinary tract infection (UTI). However, radiotherapy, long-term use of certain medicines and hygiene products have also been found to induce bladder inflammation.

Most common symptoms of cystitis are frequent urge to urinate, urge to urinate after you’ve emptied your bladder, cloudy or strong-smelling urine, pain during sexual intercourse and sensations of pressure or bladder fullness.

In serious cases, patients may also experience symptoms of fever, blood in your urine and cramping in your abdomen or back.

The prostate warped around the around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder that makes some of the semen to carry sperm.

Prostate cancer is a medical condition caused by abnormal cell growth in the tissue of the prostate. The low-growing prostate cancer may be detected during the physical (rectum) exams.

Conventionally, antibiotics are effective for the treatment of cystitis if the bacteria that cause the infection has been identified.

Most cases of acute cystitis are treated by nitrofurantoin monohydrate/macrocrystals, trimethoprim-sulfamethoxazole (TMP-SMX) accompanied by nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil) or acetaminophen (Tylenol) to reduce pain and inflammation.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of prostate diseases, researchers examined the effect of highly standardized cranberry capsules (containing 72 mg proanthocyanidins [PACS]) compared with that of placebo capsules on the incidence and severity of radiation cystitis.

The double-blinded randomized placebo-controlled study included 41 men with prostate cancer who took one capsule a day at breakfast during treatment for 2 weeks.

According to the tested analysis,

* Cranberry capsules (65%) group showed the reduced incidence of cystitis compared with those that took placebo capsules.

* The severe cystitis was reduced to 30% of men in the cranberry group compared to 45% in the placebo.

* Furthermore, cranberry capsules group also significantly reduced symptoms of pain/burning.

* Additionally, the cranberry capsules group also showed a stronger urine stream and a decrease of the used significantly fewer pads/liners, compared to placebo.

Based on the results, researchers said, "Men receiving radiation therapy for prostate cancer may benefit from using cranberry capsules, particularly those on low hydration regimens or with baseline urinary symptoms".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of cystitis.in prostate cancer patients, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: a randomized double-blinded, placebo-controlled pilot study by Hamilton K1, Bennett NC, Purdie G, Herst PM. (PubMed)
(2) Cranberry intervention in patients with prostate cancer prior to radical prostatectomy. Clinical, pathological and laboratory findings by Student V1, Vidlar A1, Bouchal J2,3, Vrbkova J3, Kolar Z2,3, Kral M1, Kosina P4, Vostalova J. (PubMed)