Healthy Food Onion Prevents the Onset of Hyperglycemia

By Kyle J. Norton

Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose.

The disease is either caused by cells in pancreas died off such as type 1 diabetes or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.

According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.

Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.

Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.

Most cases of hyperglycemia is a result of poor management of blood glucose including uncontrol diet, physical inactivity, miss-medication and improper use of insulin injection.

Believe it or not, uncontrolled diabetes or hyperglycemia over time can induce diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.

Hyperglycemia doesn't cause symptoms, however, long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) has been found to induce symptoms of frequent urination,  increased thirst, blurred vision, fatigue, and headache.

In severe cases, depending on the levels of blood glucose, some patients may also experience life-threatening complication such as fruity-smelling breath, shortness of breath, weakness, confusion and
coma.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

With an aim to find a potential and natural compound for the prevention and treatment of hyperglycemia, researchers examined the effects of onion on blood glucose in breast cancer patients

In the parallel-design, randomized, triple-blind, controlled clinical trial conducted on 56 eligible BC patients (aged 30-63 years), diagnosed with invasive ductal carcinoma, patients, following their second cycle of chemotherapy, subjects were assigned in a stratified-random allocation to receive body mass index-dependent 100 to 160 g/d of onion as high onion group (HO; n = 28) or 30 to 40 g/d small onions in low onion group (LO; n = 28) for 8 weeks.

According to the tested assay on a total of 23 available cases analyzed in each group, daily use of onion in the HO group showed a significant decrease in serum fasting blood glucose compared to the LO group over the period of study.

HO in the posttreatment also exhibited a significant decrease in homeostasis model of assessment-insulin resistance relative to changes in the LO group.

In other words, onion exerted the improvement of insulin sensitivity in postdose treatments compared to pre-treatment and to the LO group.

More precisely, daily use of onion in the HO group has a strong influence on the hyperglycemia through its improvement on insulin sensitivity in a dose-dependent manner.

Based on the findings, researchers said, "The present study demonstrated the effectiveness of onion to ameliorate hyperglycemia...in BC during doxorubicin-based chemotherapy".

Additionally, in vivo, experimental rats induced with streptozotocin and diabetic rats fed with 10% fenugreek or 3% onion or their combination for 6 weeks showed a significant effect on hyperglycemia.

Compared to control, diabetic rats in the intervention group excreted lesser glucose, albumin, urea, and creatinine, which were accompanied by improved body weights.

Fenugreek or 3% onion or their combination for 6 weeks not only inhibited the expression of hyperglycemia but also improve the parameters associated with the onset of the condition by countering metabolic abnormalities and pancreatic pathology.

Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Consumption of Fresh Yellow Onion Ameliorates Hyperglycemia and Insulin Resistance in Breast Cancer Patients During Doxorubicin-Based Chemotherapy: A Randomized Controlled Clinical Trial by Jafarpour-Sadegh F1, Montazeri V1,2, Adili A1, Esfehani A1, Rashidi MR1, Pirouzpanah S. (PubMed)
(2) Amelioration of hyperglycemia and associated metabolic abnormalities by a combination of fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in experimental diabetes by Pradeep SR1, Srinivasan K1. (PubMed)